Ⅲ期黑色素瘤围手术期治疗的现状与展望

Current status and prospect of perioperative treatment of stageⅢmelanoma

黑色素瘤是一种恶性程度极高的肿瘤,早期黑色素瘤经手术切除多可治愈,但对于高危型病例(ⅡB~Ⅳ期),辅助治疗是延长患者生命、改善预后的重要手段。近年来随着系统治疗药物的蓬勃发展,对于Ⅲ期可切除病例的围手术期治疗理念不断发生变化。本文着眼于外科手术规范及对预后的影响、术后辅助治疗选择、新辅助治疗的进展等热点问题进行梳理,并结合来源于中国患者的治疗数据进行分析讨论,希望为中国Ⅲ期黑色素瘤的围手术期治疗选择提供新的思路。

Melanoma is one of the most dangerous tumors due to its high-grade malignancy.Though patients in early stage can be completely cured by surgery,for high-risk cases(stageⅡB-Ⅳ),adjuvant therapy is of great importance to prolong the survival and improve the prognosis.In recent years,thanks to the booming development of systemic regimen,the perioperative managements for stageⅢcases have been continuously evolving.In the current paper,we focused on the role of lymph node biopsy and surgical resection,postoperative adjuvant therapy options,as well as the cutting-edge neoadjuvant therapy development,aiming to provide new perioperative strategies for stageⅢmelanoma patients.