富血小板血浆联合运动疗法在膝骨关节炎中的短期疗效观察

Observation on the short-term effect of PRP combined with exercise therapy in the treatment of knee osteoarthritis

目的:探讨富血小板血浆(platelet-rich plasma,PRP)关节腔内注射联合运动疗法与单纯PRP疗法在膝骨关节炎治疗中的疗效。方法:选取2021年4—7月于郑州大学第一附属医院骨科就诊的膝骨关节炎(Kellgren-Lawrence分级均为Ⅱ级)患者40例,随机分为PRP组和PRP联合运动疗法组,PRP组20例采用PRP注射治疗,PRP联合运动疗法组20例采用PRP注射治疗联合运动疗法。观察对比治疗后1个月两组患者的视觉模拟评分法(visual analogue scale,VAS)、20米步行时间测定、起立-行走计时测试并进行统计学分析。结果:与治疗前相比,PRP组和PRP联合运动疗法组在治疗后1个月的VAS评分、20米步行时间测定、起立-行走计时测试评分均明显降低,差异有统计学意义(P<0.05);治疗后1个月PRP联合运动疗法组的测试评分与同期PRP组相比,差异有统计学意义(P<0.05)。结论:两组在治疗膝骨关节炎中都具有显著疗效;PRP联合运动疗法相比单纯PRP注射在膝骨关节炎治疗中具有更好的治疗效果,运动疗法具有简单易行的优势。

Objective:This study intends to investigate the efficacy of intra-articular injection of platelet-rich plasma(PRP)combined with exercise therapy and simple PRP therapy in the treatment of knee osteoarthritis.Method:40 patients with knee osteoarthritis in our hospital from April to July 2021 were randomly divided into control group(n=20)and experimental group(n=20).The control group were treated with PRP injection and the experimental group were treated with PRP injection combined with exercise therapy.One month after treatment,the VAS score,20-meter walking time,stand-up-walking timing test and statistical analysis were observed and compared between the two groups.Result:Compared with those before treatment,the VAS score,20 m walking time and stand-up-walking timing test scores of the control group and the experimental group decreased significantly 1 month after treatment,and the difference was statistically significant(P<0.05).One month after treatment,the test score of the experimental group was significantly different from that of the control group(P<0.05).Conclusion:Both groups have significant curative effect in the treatment of knee osteoarthritis;PRP combined with exercise therapy has a better therapeutic effect than simple PRP injection in the treatment of knee osteoarthritis,and exercise therapy is simple and easy,so it is suitable to be popularized on the basis of orthopedic PRP treatment.