ceRNA调控网络在冠心病中的研究进展

Progress of ceRNA regulatory network in coronary atherosclerotic heart disease

冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease,CHD)是威胁人类健康的严重疾病之一,深入研究其病理机制对于其诊疗具有重要意义。非编码RNA(non-coding RNA,ncRNA)在CHD的发生、发展中发挥重要作用,而竞争性内源RNA(competing endogenous RNA,ceRNA)揭露了ncRNA在CHD中的关键作用。各种ncRNA、假基因、病毒转录物作为ceRNAs参与CHD的血管内皮损伤与修复、血管新生、脂质代谢、细胞外基质降解、炎症反应、细胞衰老、氧化应激损伤等病理过程。此外,部分ncRNAs还具有诊断和治疗的作用。深入研究ceRNA调控机制在CHD中的关键作用,对于CHD的病理机制研究、早期诊断、靶向药物研制具有重要的参考和借鉴价值。

Coronary atherosclerotic heart disease(CHD) is one of fatal disease that threatens human health, and in-depth study of its pathological mechanism is important for its diagnosis and treatment. Non-coding RNA(ncRNA) plays an important role in the development of CHD, and competing endogenous RNA(ceRNA) exposes the key role of ncRNA in CHD. Various ncRNA, pseudogenes, and viral transcripts as ceRNAs are involved in the pathological processes of vascular endothelial injury and repair, vascular neogenesis, lipid metabolism, extracellular matrix degradation, inflammatory response, cellular senescence, and oxidative stress damage in CHD. In addition, some ncRNAs have diagnostic and therapeutic roles. In-depth study of the key role of ceRNA regulatory mechanisms in CHD has an important reference value for the study of pathological mechanisms, early diagnosis, and targeted drug development in CHD.