miRNA与慢性非细菌性前列腺炎相关研究进展

Research progress of mi RNA and chronic nonbacterial prostatitis

慢性非细菌性前列腺炎(chronic nonbacterial prostatitis,CNP),暨Ⅲ型前列腺炎占全部前列腺炎患者90%以上,其病程长,易反复,因病机不明,临床疗效欠佳。目前国内外部分学者研究发现CNP患者前列腺液(expressed prostatic secretion,EPS)或CNP大鼠模型前列腺组织中的microRNA(miRNA)存在差异性表达,通过干预miRNA的表达在一定程度上可以缓解CNP的症状和药效药理学指标,这可能为CNP发病机制及诊疗的研究提供了新的途径和方向。因此,本文综述了近年miRNA与CNP相关的研究进展。

Chronic nonbacterial prostatitis(CNP),also the typeⅢprostatitis account for more than 90%of all patients with prostatitis.It has a long course of disease,easy to repeat,unknown pathogenesis and poor clinical efficacy.At present,some scholars at home and abroad have found that there is differential expression of microRNA(miRNA)in prostatic fluid of CNP patients or prostate tissue of CNP rat model.Intervention of miRNA expression can alleviate the symptoms and pharmacodynamics of CNP to a certain extent,which opens up a new way and direction for the pathogenesis and diagnosis and treatment of CNP.Therefore,this paper reviews the research progress of miRNA and CNP in recent years.