食品毒理学数据库构建研究

Construction of the Food Toxicology Database

目的 建立食品毒理学数据库(FoodTox)。方法 建立食品毒理学数据库网站,确定数据库优先入库名单,通过文献检索的方式收集相关物质的毒理学资料,利用系统文献综述(SLR)方法整理入库物质的毒理学数据。结果 食品毒理学数据库已收录1 600余种物质,相关数据包括代谢、急性毒性、遗传毒性、生殖发育毒性、亚慢性毒性、慢性毒性和致癌、人群资料、健康指导值等毒理学资料和国内外管理法规、相关食物和症状等,已经向相关领域工作者开放使用。结论 本数据库的建立将为食品毒理学工作者提供第一手的参考资料,为相关优先物质的毒理学安全性评价提供依据,为应急风险评估提供技术支持。

Objective To establish the Food Toxicology Database(FoodTox).Methods A food toxicology database website was established. The priority list of the database was determined. The toxicological data of related substances through literature search was collected,and the systematic literature review(SLR) method was used to sort out the toxicological data of the substances in the library.Results The food toxicology database has collected more than 1 600substances with related data including toxicology-related information such as metabolism,acute toxicity,genotoxicity,reproductive and developmental toxicity,subchronic toxicity,chronic toxicity and carcinogenicity,population data,health guidance values and regulations of domestic and foreign management,related foods and symptoms etc.,which has been open to researchers in related fields.Conclusion This database will provide the related professionals with the firsthand data,rapid technical support for emergency risk assessment and reference for priority substance evaluation.