氧化应激在脓毒性心肌病中作用机制的研究进展

Research progress of mechanisms of oxidative stress in septic cardiomyopathy

脓毒症目前被定义为患者对感染的反应失调而引起的危及生命的多器官功能障碍,在重症监护病房中发病率和病死率较高。脓毒症患者常并发心功能障碍被称为脓毒性心肌病(SCM),SCM的发生与患者的高病死率相关,长期以来被密切关注,也是脓毒症系统治疗亟待解决的难题之一。目前,SCM的发病机制尚不明确,大量研究表明,氧化应激是SCM的发病机制之一,整合近年来氧化应激在SCM中的作用及针对氧化还原失衡的潜在治疗措施的相关研究进行讨论。

Sepsis is currently defined as a life-threatening multiple organ dysfunction caused by host dysregulated response to infection,with high morbidity and mortality in intensive care units.Patients with sepsis are often complicated with cardiac dysfunction known as septic cardiomyopathy(SCM).The occurrence of SCM is related to the high mortality of patients,which has been closely concerned for a long time,and is also one of the challenges to be solved in the systematic treatment of sepsis.A large number of studies have shown that oxidative stress contributes to the pathogenesis of SCM.The role of oxidative stress in SCM and the potential treatment measures for redox imbalance are discussed in this paper.