视网膜病变与脑白质病变关系的研究进展

Research progress of the relationship between retinopathy and white matter lesions

视网膜病变包括视网膜血管改变和血-视网膜屏障破坏的表现等,最终导致视网膜神经上皮层损伤,产生视觉症状。通过眼底照相及光学相干断层扫描、光学相干断层血管成像技术等手段,可以较为便捷、直观地观察视网膜病变。脑白质病变(WMLs)是脑小血管病的一种亚型。近年来,越来越多的研究结果表明,视网膜病变与WMLs密切相关,并且二者可共同为缺血性卒中风险评估提供参考依据。作者对视网膜病变与WMLs关系的相关研究进行综述,以期为WMLs的临床早期诊断及相关病因机制学研究提供参考。

Retinopathy involves retinal vascular changes and blood-retinal barrier disruption, and ultimately leads to retinal neuroepithelial layer damage, resulting in visual symptoms. By retinal fundus image, optical coherence tomography and optical coherence tomography angiography, the retinopathy can be observed conveniently and intuitively. White matter lesions(WMLs) are a subtype of cerebral small vessel disease. Recently, more and more research evidences suggest that retinopathy is closely related to WMLs, and both can provide reference for evaluating the ischemic stroke risk. This article reviewed the relationship between retinopathy and WMLs, to provide basis for early clinical diagnosis and related research on etiology and mechanism of the WMLs.