邻苯二甲酸酯对胆汁淤积性肝病影响的研究进展

Research advances in the impact of phthalates on cholestatic liver disease

胆汁淤积性肝病是由于胆汁生成、排泄及代谢障碍,造成胆汁在肝脏沉积所致的一类常见肝胆疾病。目前胆汁淤积性肝病的致病因素尚未充分阐明,但有研究者认为环境因素可能在其中发挥重要作用。环境污染物邻苯二甲酸酯已被证实可干扰人类内分泌系统,对人体具有潜在毒性,危及肝肾功能,且可能增加肝内胆汁淤积的发生风险。基于此,本研究对邻苯二甲酸酯与胆汁淤积性肝病的关系进行综述,分别从临床研究、动物实验研究和体外实验研究及潜在机制进行总结,为胆汁淤积性肝病的预防以及临床治疗提供思路和参考。

Cholestatic liver disease is a common hepatobiliary disease caused by bile deposition in the liver due to the disorders of bile production,excretion,and metabolism.At present,the pathogenic factors for cholestatic liver disease have not been fully elucidated,but some researchers believe that environmental factors may play an important role in it.As environmental pollutants,phthalic acid esters(PAE)have been confirmed to interfere with human endocrine system,exert a potential toxic effect on the human body,endanger liver and kidney function,and increase the risk of intrahepatic cholestasis.On this basis,this article reviews the association between PAE and cholestatic liver disease and summarizes related clinical studies,animal experimental studies,in vitro experimental studies,and potential mechanisms,so as to provide ideas and references for the prevention and clinical treatment of cholestatic liver disease.