基于CiteSpace可视化分析间充质干细胞治疗糖尿病足的研究现状及趋势

Analysis of the research status and trends of mesenchymal stem cells in the treatment of diabetic foot based on CiteSpace visualization software

目的探索间充质干细胞(MSCs)治疗糖尿病足的研究现状,研究热点和研究趋势。方法本文利用分析软件CiteSpace和文献管理软件EndNote,运用可视化分析方法对近10年内Web of science数据库中收录的MSCs用于治疗糖尿病足的研究文献数据进行处理,从研究作者、研究机构、科学分类和关键词等方面绘制知识图谱。结果共纳入231篇文献。(1)研究热点主要包括创面修复、血管新生、生长因子和诱导分化等;(2)旁分泌作用和诱导分化机制在糖尿病足的皮肤再生和伤口愈合中发挥有益作用;(3)突变词(2020年至2022年)主要包括"脂肪源间充质干细胞"与"临床试验";(4)在领域交流合作方面我国的研究机构和学者占主导地位,且在研究学科上呈多学科研究趋势。结论通过可视化分析初步展示近10年糖尿病足的研究现状、热点与趋势,且描绘MSCs治疗糖尿病足的临床应用与价值,为今后糖尿病足的研究工作提供有益参考和借鉴。

Objective To explore the research status,hotspots and frontiers of mesenchymal stem cells(MSCs)in treating of the diabetic foot.Methods The visual analysis method was used to analyze the related literature of MSCs in the diagnosis and prevention of diabetic foot based on CiteSpace and EndNote software,which were searched in the core database of Web of Science in the last ten years,and the knowledge mapping of keywords,authors,institutions and other aspects were drawn.Results A total of 231 works of literature were included.(1)The research hotspots of MSCs in treating of diabetic foot mainly included wound healing,angiogenesis,growth factor and differentiation,etc.(2)Keywords of emergence(2020-2022)mainly consist of adipose-derived mesenchymal stem cells and clinical trials.(3)Paracrine and differentiation properties play beneficial roles in the wound healing of diabetic foot.(4)In communication and cooperation,research institutions and authors in our country have played a leading role,and the trend of multi-disciplinary research emerges in research subjects.Conclusion The current research status,hotspots and frontiers of diabetic foot in the past ten years were preliminarily demonstrated by using visual analysis,but also the clinical application of MSCs in the treatment of diabetic foot were also described,which provides valuable reference for the future research of diabetic foot.