金黄色葡萄球菌抗肿瘤作用的研究进展

Progress in the antitumor effects of Staphylococcus aureus

基于生物药物和细胞免疫疗法的恶性肿瘤治疗应用备受关注。免疫疗法是抗肿瘤的重要方法,其目标是激活机体的自身免疫系统,特异性识别和杀伤肿瘤细胞。金黄色葡萄球菌是人类常见的病原体,有“嗜肉菌”之称,为革兰阳性菌的代表,可以引起严重的化脓性感染,在感染过程中会导致细胞坏死和凋亡。利用金黄色葡萄球菌促细胞凋亡的功能,可作为癌症治疗的潜在工具。对金黄色葡萄球菌分泌的毒素进行研究,发现金黄色葡萄球菌释放的多种毒素和酶是免疫系统的有效激活剂。在毒素激活的免疫细胞的帮助下,机体对多种癌细胞表现出了良好的抗肿瘤活性。本文综述了金黄色葡萄球菌分泌的毒素因子,讨论了其抗肿瘤活性和发挥抗肿瘤的机制。

The application of biological drugs and cellular immunotherapy in the treatment of malignant tumors has attracted much attention.Immunotherapy is an important anti-tumor method,and its goal is to activate the body’s own immune system and to specificallyrecognize and kill tumor cells.Staphylococcus aureus(S.aureus) which is the nickname "carniophilia",has been a common pathogen in humans.It is a representative of gram-positive bacteria,which can cause many serious suppurative infections,and necrosis or apoptosis of cells during infection.S.aureus can be used as a potential tool for cancer therapy by exploiting its pro-apoptotic function.Studies on the toxins secreted by S.aureus have found that a variety of toxins and enzymes released by S.aureus are effective activators of the immune system.With the help of toxin-activated immune cells,the body exhibits good anti-tumor activity against a variety of cancer cells.In this paper,the toxic factors secreted by S.aureus were reviewed,and the anti-tumor activities and mechanisms of its anti-tumor activities were discussed.