甲巯咪唑片治疗甲状腺功能亢进症的效果研究

Study on Effect of Methimazole Tablets in Treatment of Hyperthyroidism

目的:探讨甲巯咪唑片治疗甲状腺功能亢进症(甲亢)的疗效。方法:选取2017年5月—2020年6月本院诊治的甲亢患者148例作为研究对象,根据治疗方法不同分为两组,各74例。对照组给予丙硫氧嘧啶治疗,研究组给予甲巯咪唑治疗,比较两组临床疗效、甲状腺体积及血清指标。结果:研究组治疗总有效率为98.6%,高于对照组的90.5%(P<0.05);研究组治疗后甲状腺体积、FT3水平、FT4水平、甘油三酯、低密度脂蛋白胆固醇低于对照组(P<0.05)。结论:甲巯咪唑片治疗甲亢的效果良好,可缩小甲状腺体积,抑制甘油三酯、低密度脂蛋白胆固醇表达,改善甲状腺激素水平,值得临床应用。

Objective: To investigate the efficacy of methimazole tablets in the treatment of hyperthyroidism. Methods: A total of 148 patients with hyperthyroidism diagnosed and treated in our hospital from May 2017 to June 2020 were selected as the research objects. They were divided into two groups according to different treatment methods, with 74 cases in each group. The control group was treated with propylthiouracil, and the study group was treated with methimazole. The clinical efficacy, thyroid volume and serum indexes were compared between the two groups. Results: The total effective rate of treatment in the study group was 98.6%, which was higher than 90.5% in the control group(P<0.05). After treatment, the thyroid volume, FT3 level, FT4 level, triglyceride and low density lipoprotein cholesterol in the study group were lower than those in the control group(P<0.05). Conclusion: Methimazole tablets have a good effect in the treatment of hyperthyroidism,which can reduce thyroid volume, inhibit the expression of triglyceride and low density lipoprotein cholesterol, improve thyroid hormone levels, and is worthy of clinical application.