不同剂量丁二磺酸腺苷蛋氨酸联合恩替卡韦分散片治疗乙型病毒性肝炎的效果

Effect of Different Doses of Adenosylmethionine Succinate Combined with Entecavir Dispersible Tablets in the Treatment of Viral Hepatitis B

目的:比较不同剂量注射用丁二磺酸腺苷蛋氨酸治疗乙型病毒性肝炎(CHB)的疗效。方法:选取本院2016年1月—2021年1月就诊的CHB患者90例开展研究,按照随机数字表法将其分为观察组、对照组,每组45例。对照组予以小剂量注射治疗(1000 mg),而观察组则予以大剂量注射治疗(2000 mg),比较两组临床疗效、肝功能指标改善情况及不良反应发生率。结果:治疗后,观察组治疗总有效率为95.56%,高于对照组的82.22%(P<0.05);观察组丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、谷氨酸转肽酶(GGT)、碱性磷酸酶(ALP)优于对照组(P<0.05);观察组并发症发生率为4.44%,与对照组的13.33%比较,差异无统计学意义(P>0.05)。结论:不同剂量的注射用丁二磺酸腺苷蛋氨酸应用于乙型病毒性肝炎的效果不同,2000 mg的注射治疗效果更好,可改善患者肝功能,安全性较好,值得临床应用。

Objective: To compare the efficacy of different doses of adenosylmethionine succinate for injection in the treatment of viral hepatitis B(CHB). Methods: Ninety patients with CHB who were treated in our hospital from January 2016 to January 2021 were selected for the study. They were divided into observation group and control group according to the random number table method, with 45 cases in each group. The control group was treated with low-dose injection(1000 mg), while the observation group was treated with high-dose injection(2000 mg). The clinical efficacy, improvement of liver function indexes and incidence of adverse reactions were compared between the two groups. Results: After treatment, the total response rate of the observation group was 95.56%, which was higher than the 82.22% of the control group(P<0.05).The alanine aminotransferase(ALT), total bilirubin(TBIL), glutamic acid transpeptidase(GGT) and alkaline phosphatase(ALP) in the observation group were better than those in the control group(P<0.05). The incidence of complications in the observation group was 4.44%, which was compared with 13.33% in the control group, the difference was not statistically significant(P>0.05).Conclusion: Different doses of adenosylmethionine succinate for injection have different effects on viral hepatitis B. The injection of 2000 mg has better therapeutic effect, can improve the liver function of patients, and has better safety, which is worthy of clinical application.