甲泼尼龙联合异丙托溴铵治疗慢性阻塞性肺气肿的疗效

Efficacy of Methylprednisolone Combined with Ipratropium Bromide in Treatment of Chronic Obstructive Pulmonary Emphysema

目的:探讨甲泼尼龙联合异丙托溴铵治疗慢性阻塞性肺气肿的效果。方法:选取2021年1月—12月我院呼吸科收治的80例慢性阻塞性肺气肿患者作为研究对象,采用随机数字表法分成观察组与对照组,每组40例,对照组采用异丙托溴铵治疗,观察组在此基础上联合甲泼尼龙治疗,比较两组肺功能情况(用力肺活量、第一秒呼气容积、最大呼气中期流量)、临床疗效以及不良反应发生情况。结果:观察组用力肺活量、第一秒呼气容积以及最大呼气中期流量优于对照组(P<0.05);观察组治疗总有效率为95.00%,高于对照组的67.50%(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:甲泼尼龙联合异丙托溴铵治疗慢性阻塞性肺气肿的疗效确切,可提升肺功能,且联合用药不增加不良反应发生概率,具有应用安全性。

Objective: To investigate the effect of methylprednisolone combined with ipratropium bromide in the treatment of chronic obstructive pulmonary emphysema. Methods: From January 2021 to December 2021,80 patients with chronic obstructive pulmonary emphysema admitted to the respiratory department of our hospital were selected as the research objects. They were divided into observation group and control group by random number table method, 40 cases in each group.The control group was treated with ipratropium bromide, and the observation group was treated with methylprednisolone on this basis. The pulmonary function( forced vital capacity, first second expiratory volume, maximum mid-expiratory flow),clinical efficacy and adverse reactions were compared between the two groups. Results: The forced vital capacity, first second expiratory volume and maximum mid-expiratory flow in the observation group were better than those in the control group(P<0.05). The total effective rate of treatment in the observation group was 95.00%, which was higher than 67.50% in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Methylprednisolone combined with ipratropium bromide is effective in the treatment of chronic obstructive pulmonary emphysema, which can improve lung function, and the combination does not increase the incidence of adverse reactions, with application safety.