补肾祛风通络方联合氨甲蝶呤治疗老年类风湿关节炎患者的效果

Effects of Bushen Qufeng Tongluo decoction combined with Methotrexate in treatment of elderly patients with rheumatoid arthritis

目的:观察补肾祛风通络方联合氨甲蝶呤治疗老年类风湿关节炎患者的效果。方法:选取2019年5月至2021年5月该院收治的90例老年类风湿性关节炎患者进行前瞻性研究,按随机数字表法将其分为观察组与对照组各45例。对照组给予氨甲蝶呤治疗,观察组在对照组基础上联合补肾祛风通络方治疗,比较两组临床疗效、治疗前后中医证候积分、临床症状和不良反应发生率。结果:观察组治疗总有效率为95.56%(43/45),高于对照组的80.00%(36/45),差异有统计学意义(P<0.05);两组中医证候积分均低于治疗前,且观察组低于对照组,差异统计学意义(P<0.05);两组关节肿胀个数、关节压痛个数均少于治疗前,且观察组少于对照组,两组晨僵时间均短于治疗前,且观察组短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:补肾祛风通络方联合氨甲蝶呤治疗老年类风湿关节炎患者可提高治疗总有效率,降低中医证候积分,加快症状缓解,其效果优于单纯氨甲蝶呤治疗。

Objective: To observe effects of Bushen Qufeng Tongluo decoction combined with Methotrexate in treatment of elderly patients with rheumatoid arthritis. Methods: A retrospective study was conducted on the clinical data of 90 elderly patients with rheumatoid arthritis admitted to this hospital from May 2019 to May 2021. They were divided into observation group and control group according to the random number table method, 45cases in each. The control group was treated with Methotrexate tablets, while the observation group was treated with Bushen Qufeng Tongluo decoction on the basis of that of the control group. The clinical efficacy, the TCM syndrome scores before and after the treatment, the levels of clinical symptom indexes,and the incidence of adverse reactions were compared between the two groups. Results: The total effective rate of treatment in the observation group was 93.33 %(42/45), which was higher than 80.00%(36/45) in the control group, and the difference was statistically significant(P<0.05). The TCM syndrome scores of the two groups were lower than those before the treatment, those of the observation group were lower than those of the control group, and the difference was statistically significant(P<0.05). The numbers of joint swelling and joint tenderness in the two groups were lower than those before the treatment, and those of the observation group was lower than those of the control group;the morning stiffness time of the two groups were shorter than those before the treatment, and that of the observation group was shorter than that of the control group;and the differences were statistically significant(P<0.05).However, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusions: Bushen Qufeng Tongluo decoction combined with Methotrexate in the treatment of the elderly patients with rheumatoid arthritis can improve the total effective rate, reduce the TCM syndrome score and improve the levels of clinical symptoms. Moreover, it is superior to single Methotrexate tablets treatment.