临床药学服务在头孢菌素类药物临床合理应用中的效果

Effects of clinical pharmaceutical services on clinical rational application of Cephalosporins

目的:观察临床药学服务在头孢菌素类药物临床合理应用中的效果。方法:选取2017年12月至2019年12月该院收治的80例接受头孢菌素类药物治疗的患者进行前瞻性研究。按照随机数字表法分为对照组和观察组各40例。对照组实施常规用药干预,观察组在对照组基础上实施临床药学服务,比较两组用药依从性,认知水平,干预前后炎性因子[C反应蛋白(CRP)、降钙素原(PCT)]水平,不合理用药事件发生率及不良反应发生率。结果:观察组用药依从性为95.00%,高于对照组的77.50%,差异有统计学意义(P<0.05);观察组药物性质、用药方式、配伍禁忌、用药安全等各项认知水平均高于对照组,差异有统计学意义(P<0.05);观察组CRP、PCT水平均低于对照组,差异有统计学意义(P<0.05);观察组不合理用药发生率为2.50%,低于对照组的20.00%,差异有统计学意义(P<0.05);观察组不良反应发生率为5.00%,低于对照组的22.50%,差异有统计学意义(P<0.05)。结论:临床药学服务干预应用于头孢菌素类药物合理运用,可提高用药依从性和用药认知水平,降低炎性因子水平,减少不合理用药事件发生率和不良反应发生率,其效果优于单纯常规干预。

Objective: To observe effects of clinical pharmaceutical services on clinical rational application of Cephalosporins. Methods:A prospective study was conducted on 80 patients who were treated with Cephalosporins from December 2017 to December 2019. According to random number table method, they were divided into control group and observation group, 40 cases in each group. The control group was given routine medication intervention, while the observation group was given clinical pharmaceutical services on the basis of that of the control group. The medication compliance, the cognitive level, the levels of inflammatory factors [C-reactive protein(CRP) and procalcitonin(PCT)] before and after the intervention, the incidence of irrational drug use events, and the incidence of adverse reactions were compared between the two groups. Results: The medication compliance of the observation group was 95.00%, which was higher than 77.50% of the control group, and the difference was statistically significant(P<0.05). The cognitive levels of drug properties, medication methods, incompatibility and medication safety in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). The levels of CRP and PCT in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). The incidence of irrational drug use in the observation group was 2.50%, which was lower than 20.00% in the control group, and the difference was statistically significant(P<0.05). Further,the incidence of adverse reactions of the observation group was 5.00%, which was lower than 22.50% in the control group, and the difference was statistically significant(P<0.05). Conclusions: The clinical pharmaceutical service intervention for the rational use of Cephalosporins can the improve medication compliance and the medication cognition levels, reduce the levels of inflammatory factors, and reduce the incidences of irrational drug use events and adverse reactions. Moreover, it is superior to simple routine intervention.