血栓弹力图与传统凝血四项在重型颅脑损伤预后相关性中的应用新进展

New advances in the application of thromboelastography and traditional four coagulation parameters in the prognosis of severe traumatic brain injury

颅脑创伤是一种常见的损伤类型,而在重型颅脑损伤后出血机制和血栓形成平衡可以改变。止血功能受损可能会加重原发性损伤,并有引发或加重出血的风险。在许多创伤性脑损伤患者受伤入院时常规凝血试验都有异常,然而这些凝血异常对重型颅脑损伤预后的影响程度以及它们是否是可改变的危险因素尚不清楚。而对于凝血功能障碍的研究,国内外应用血栓弹力图来更精确地反映凝血功能障碍和颅脑损伤程度的关系。该文将凝血功能障碍与重型颅脑损伤的研究现状做一综述。

Traumatic brain injury is a common type of injury,and there are often changes in the mechanism of bleeding and the balance of thrombosis after severe traumatic brain injury.Impaired hemostasis may exacerbate primary injury and have the risk of inducing or aggravating bleeding.Many patients with traumatic brain injury are found to have abnormalities in conventional coagulation tests on admission,while further studies are needed to clarify the extent to which these coagulation abnormalities affect the prognosis of severe traumatic brain injury and whether they are modifiable risk factors.For the research on coagulation disorders,thromboelastography is used in China and globally to more accurately reflect the association between coagulation disorders and the severity of traumatic brain injury.This article reviews the current status of the research on coagulation disorders and severe traumatic brain injury.