孟鲁司特钠联合益生菌对嗜酸性粒细胞性胃肠炎患儿肥大细胞数量和IL-5表达量的影响

Impacts of montelukast sodium combined with probiotics on MC number and IL-5 expression in children with eosinophilic gastroenteritis

目的探讨嗜酸性粒细胞性胃肠炎(EG)患儿采用孟鲁司特钠联合益生菌对肥大细胞(MC)数量和白介素-5(IL-5)表达量的影响。方法选取无锡市儿童医院2019年1月至2022年2月收治入院的84例EG患儿作为研究对象。根据不同的治疗方式将其分为对照组和试验组,每组各42例。对照组采用孟鲁司特钠治疗,试验组在对照组的基础上联合益生菌治疗。比较两组临床症状消失时间,治疗前后的血清指标水平、电镜下胃黏膜嗜酸性粒细胞(EOS)、MC数量以及肠道菌群数量。结果试验组呕吐消失时间、腹泻消失时间和发热消失时间均短于对照组,差异有统计学意义(P<0.05);治疗4周后,试验组IL-5和免疫球蛋白E(IgE)指标水平明显低于对照组,差异有统计学意义(P<0.05);试验组免疫球蛋白M(IgM)水平明显高于对照组,差异有统计学意义(P<0.05);治疗4周后,试验组EOS和MC数量明显少于对照组,差异有统计学意义(P<0.05);治疗4周后,试验组双歧杆菌和乳酸杆菌数量明显高于对照组,差异有统计学意义(P<0.05);试验组肠球菌和大肠埃希菌数量明显低于对照组,差异有统计学意义(P<0.05)。结论孟鲁司特钠联合益生菌对EG患者MC数量和IL-5表达量有明显的抑制作用,可加快临床症状消失,值得推广应用。

Objective To investigate the impacts of montelukast sodium combined with probiotics on mast cells(MC)number and interleukin-5(IL-5)expression in children with eosinophilic gastroenteritis(EG).Methods A total of 84 children with EG admitted to and treated in Wuxi Children’s Hospital from January 2019 to February 2022 were selected as the research objects.According to different treatment methods,they were divided into the control group(n=42)and the experimental group(n=42).The control group was treated with montelukast sodium,while the experimental group was treated with probiotics on the basis of the control group.The disappearance time of clinical symptoms,the serum indices levels,and the number of eosinophils(EOS),MC and intestinal flora in gastric mucosa under electron microscope before and after treatment were compared between the two groups.Results The disappearance time of vomiting,diarrhea and fever in the experimental group was all shorter than that in the control group,with statistically significant differences(P<0.05).After 4 weeks of treatment,the indices levels of IL-5 and immunoglobulin E(IgE)in the experimental group were remarkably lower than those in the control group,with statistically significant differences(P<0.05).The level of immunoglobulin M(IgM)in the experimental group was remarkably higher than that in the control group,with statistically significant difference(P<0.05).After 4 weeks of treatment,the number of EOS and MC in the experimental group was remarkably less than that in the control group,with statistically significant difference(P<0.05).After 4 weeks of treatment,the number of Bifidobacterium and Lactobacillus in the experimental group was remarkably higher than that in the control group,with statistically significant difference(P<0.05).The number of enterococcus and Escherichia coli in the experimental group was remarkably lower than that in the control group,with statistically significant difference(P<0.05).Conclusion Montelukast sodium combined with probiotics can obviously inhibit the number of MC and the expression of IL-5 in patients with EG,and accelerate the disappearance of clinical symptoms.Therefore,i t is worthy of promotion and application.