中药对自身免疫性疾病细胞焦亡影响的研究进展

Effect of Chinese Medicine on Pyroptosis of Autoimmune Disease:A Review

细胞焦亡是近年发现的一种细胞程序性死亡方式,由胱天蛋白酶(Caspase)介导,可导致细胞内炎性物质等释放到细胞外,诱发炎症级联反应。自身免疫性疾病(ADs)是一类机体免疫耐受受损、过量产生自身抗体,导致自身组织损害的疾病,其致病因素复杂,发病机制尚不明确。随着对细胞焦亡研究的深入,越来越多的结果表明细胞焦亡参与类风湿关节炎、溃疡性结肠炎、系统性红斑狼疮和银屑病等多种ADs的发病过程。临床治疗ADs多采用糖皮质激素类药物、抗风湿药物和生物制剂等,但是部分药物的治疗效果有限,且长期用药存在一些不良反应。中药治疗ADs在长期临床实践中证实了其安全性和有效性,具有多靶向性、不良反应小等特点,在控制病程方面有一定的优势。越来越多的研究发现多种中药组方制剂、单味药材和中药活性成分,发挥药效的机制可能是通过干预细胞焦亡从而治疗ADs。因此,该文综述了近年来中药对ADs中细胞焦亡影响的实验研究,以期为临床治疗和科学研究提供参考。

Pyroptosis is a recently discovered programmed cell death mediated by cysteinyl aspartate specific proteinase(Caspase),which may lead to the release of intracellular inflammatory substances to extracellular and induce inflammatory cascades.Autoimmune diseases(ADs)is a kind of disease in which the body’s immune tolerance is impaired,and the body overproduces autoantibodies,causing damage to its tissues.The pathogenic factors of ADs are complex and the pathogenesis is still unclear.With the deepening of the research on pyroptosis,more and more results show that pyroptosis is involved in the pathogenesis of various ADs such as rheumatoid arthritis,ulcerative colitis,systemic lupus erythematosus,and psoriasis.Glucocorticoid drugs,anti-rheumatism drugs,and biological agents are mostly used in the clinical treatment of ADs,but the therapeutic effect of some drugs is limited,and there are some long-term adverse reactions.Chinese medicine in the treatment of ADs has been proven to be safe and effective in long-term clinical practice.It has the characteristics of multiple targets and few side effects and has certain advantages in controlling the course of the disease.More and more studies have found that a variety of Chinese medicine formulations,single Chinese medicine,and active ingredients of Chinese medicine treat ADs through the intervention of pyroptosis.Therefore,this paper reviewed the experimental studies on the effect of Chinese medicine on pyroptosis in ADs in recent years,hoping to provide references for clinical treatment and scientific research.