结直肠癌腹膜转移的治疗

Treatment of peritoneal metastasis of colorectal origin

全球结直肠癌发病率逐年增加,对于无远处播散的患者,手术切除原发肿瘤和区域淋巴结清扫是唯一可能治愈的方法。但一些患者仍会出现肝脏、肺和腹膜等部位转移。全身化疗联合肿瘤细胞减灭术(cytoreductive surgery,CRS)联合腹腔热灌注化疗(hyperthermic intraperitoneal chemotherapy,HIPEC)应作为腹膜转移癌的标准治疗,是迄今治疗效果最好的方案。本文将对结直肠腹膜转移的发病现状、机制、特点及诊疗进展进行综述。

The global incidence of colorectal cancer is increasing year by year, and for patients without distant spread, surgical resection of the primary tumor and regional lymph node dissection are the only possible treatments. However, some patients still develop metastases in the liver, lungs, and peritoneum. This article reviews the present situation, mechanism, characteristics and progress of diagnosis and treatment of colorectal peritoneal metastasis. Systemic chemotherapy combined with CRS+HIPEC should be regarded as the standard treatment for peritoneal metastases, which is by far the most effective treatment regimen.