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Selenium-Sulfur-Doped Carbon Dots with Thioredoxin Reductase Activity

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摘要 Thioredoxin reductase(TrxR)is an essential enzyme for regulating the redox balance in cells,promoting cell proliferation,and inhibiting cellular apoptosis.The biochemical pathway of TrxR metabolism involves a series of selenium-sulfur(Se-S)dynamic chemistry.Theoretically,nanomaterials with Se-S dynamic bonds could exhibit TrxRmimetic activities to tune TrxR activity,affecting cellular activities.Herein,we report the fabrication of Se-S-doped carbon dots(Se-S-CDs),synthesized by a facile hydrothermal method.The Se-S-CDs exhibited good stability and solubility in an aqueous solution,with a quantum yield of 13.27%.The doping of Se-S bonds endowed the Se-S-CDs with great capability of enhancing the TrxR activity,and consequently,a remarkable promotion of cell viability.The significance of Se-S bonds,as well as CDs’role as matrices,are discussed.Moreover,the Se-S-CDs could also revive the cells from the damage induced by oxidative stress.The abovementioned properties demonstrated the potential of the Se-S-CDs for cells and tissues culturing,solving the poor cell viability issue,which is desperately needed for organ transplantation and revitalization of prematurely aging cells,especially those exposed to oxidative stress.
出处 《CCS Chemistry》 CAS 2022年第7期2239-2248,共10页 中国化学会会刊(英文)
基金 supported financially by the National Basic Research Plan of China(no.2018YFA208900) the National Natural Science Foundation of China(no.21734004) the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(no.21821001).
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