F-PLR评分对局晚期宫颈癌预后的影响

Effect of F-NLR Score on Prognosis of Local Advanced Cervical Cancer

目的探讨治疗前血清纤维蛋白原和血小板/淋巴细胞比值评分(plasma fibrinogen level and platelet-to-lymphocyte ratio,F-PLR)在局晚期宫颈癌(local advanced cervical cancer,LACC)患者预后中的价值。方法回顾性分析2014年1月~2018年1月在徐州医科大学附属医院收治的137例LACC患者的临床及随访资料,使用受试者工作特征(receiver operating characteristic,ROC)曲线确定纤维蛋白原(fibrinogen,FIB)和血小板/淋巴细胞比值(platelet-to-lymphocyte ratio,PLR)预测无进展生存期(progression-free survival,PFS)的最佳截断值。根据FIB≥截断值和PLR≥截断值两项预后因素将F-PLR分为3组,即FIB和PLR均低于最佳截断值为0分,有1项高于最佳截断值为1分,都高于最佳截断值为2分,比较3组临床特征,并分析F-PLR在预测LACC患者预后中的价值。结果FIB的最佳截断值是3.510,PLR的最佳截断值是146.760,对患者临床特征分析发现,F-PLR评分与临床分期和淋巴结转移显著相关(P<0.05)。F-PLR评分为0分组生存率明显高于1分和2分组,5年PFS分别为89.2%、70.2%和47.2%(P<0.05)。5年总生存期(overall survival,OS)分别为94.6%、78.7%和69.8%(P<0.05)。COX多因素分析表明,治疗前F-PLR评分是影响患者PFS和OS的独立预后因素(P<0.05)。结论F-PLR评分可以预测LACC患者的预后,对于判断患者预后具有一定价值。

Objective To explore the prognostic value of serum fibrinogen and platelet-to-lymphocyte ratio score(plasma fibrinogen level and platelet-to-lymphocyte ratio,F-PLR)in patients with locally advanced cervical cancer(local advanced cervical cance,LACC).Methods The clinical and follow-up data of 137 patients with LACC diagnosed for the first time in the Affiliated Hospital of Xuzhou Medical University from January 2014 to January 2018 were analyzed retrospectively.The optimal cutoff value of fibrinogen(fibrinogen,FIB)and platelet-to-lymphocyte ratio(platelet-to-lymphocyte ratio,PLR)for predicting progression-free survival(progression-free survival,PFS)was determined by receiver operating characteristic curve(ROC).According to the two prognostic factors of FIB≥truncation value and PLR≥truncation value,F-PLR was divided into three groups:FIB and PLR were all lower than the optimal cut off value(0 score),one item was higher than the optimal truncation value(1 score),and higher than the optimal truncation value(2 scores).The clinical features of the three groups were compared,and the value of F-PLR in predicting the prognosis of patients with LACC was analyzed.Results The best cut-off value of FIB was 3.510 and the best cut-off value of F-PLR was 146.760.According to the analysis of clinical characteristics,it was found that F-PLR score was significantly correlated with clinical stages and lymph node metastasis.According to F-PLR score,the survival rate of group 0 was significantly higher than that of group 1 and 2,and the 5-year PFS was 89.2%,70.2%and 47.2%,respectively(P<0.05).The 5-year overall survival time(overall survival,OS)was 94.6%,78.7%and 69.8%,respectively(P<0.05).COX multivariate analysis showed that F-PLR score before treatment was an independent prognostic factor for PFS and OS.Conclusion F-PLR score can predict the prognosis of patients with LACC and has a certain value in judging the prognosis of patients.