摘要
We have disclosed a novel,efficient radicalmediated intermolecular fluoroalkylative olefination of unactivated alkenes.The transformation proceeded through a radical docking-migration cascade,in which a portfolio of strategically designed dual-function alkenylating reagents was harnessed to afford vinylated products with exclusive E-configuration.The reaction featured mild conditions,broad functional group compatibility,and unique chemo-,regio-,and stereoselectivities.The protocol has also provided a useful approach for late-stage olefination of complex natural products and drug derivatives containing alkenyl moieties.
基金
the financial support from the National Natural Science Foundation of China(grant no.21971173)
the Project of Scientific and Technologic Infrastructure of Suzhou(grant no.SZS201905)
the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
