N-P配体在铱催化不对称烯丙基取代反应中的应用研究进展

Advances in the Application of N-P Ligands in Iridium-catalyzed Asymmetric Allylic Substitution Reactions

铱催化的不对称烯丙基取代反应是一种重要的合成手性化合物方法,在有机合成领域中有着非常重要的应用.该反应具有反应条件温和、产率良好、对映选择性和区域选择性优异的特点,被相关领域学者们广泛关注.本论文对近20年来尤其是近10年铱催化的不对称烯丙基取代反应的研究进行总结和概括,并提出展望.

Iridium-catalyzed asymmetric allylic substitution reaction is an important method for the synthesis of chiral compounds,which has the important application in the field of organic synthesis.Due to its mild reaction conditions,good yield,and excellent enantioselectivity and regioselectivity,the reaction has been widely concerned by scholars in related fields.In this review,the research on iridium catalyzed asymmetric allyl substitution reactions in the past 20years,especially in the past 10years,was summarized,and the prospects were put forward.