Nickel-Catalyzed Reductive Electrophilic Ring-Opening of Benzofurans with Alkyl Halides

In this paper,we developed an electrophilic ring-opening reaction,which is beyond the strained small ring system.Under reductive nickel catalysis,ring-opening of diverse benzofurans via endocyclic inert carbon–oxygen bond cleavage can be achieved with an array of inactivated secondary and tertiary alkyl halides as coupling partners,allowing for the preparation of a series of(E)-o-alkenylphenols with excellent E/Z-selectivity and high functional tolerance.The utility of this method was further demonstrated through derivatizations of the ring-opening products using the o-hydroxyl group as a functional handle,providing various organic compounds in good to high efficiency.