雾化吸入干扰素α-1b治疗小儿喘息性支气管肺炎的临床观察

Clinical Observation on Atomization Inhalation Interferonα-1b in the Treatment of Asthmatic Bronchopneumonia in Children

目的:研究雾化吸入干扰素α–1b治疗小儿喘息性支气管肺炎的临床效果。方法:选取2020年9月至2021年12月期间新乡市妇幼保健院收治的140例喘息性支气管肺炎患儿,随机分为观察组和对照组,每组70例。对照组给予布地奈德和特布他林雾化吸入治疗,观察组在对照组基础上联合干扰素α–1b雾化吸入治疗。比较两组患儿的临床症状持续时间和住院时间,治疗7 d后,观察比较两组患儿的总疗效、发病早晚期就诊的疗效、两组中呼吸道病毒检测阳性和阴性患儿的疗效以及治疗过程中的不良事件。结果:观察组患儿发热、咳嗽、喘鸣、肺部啰音、住院时间均短于对照组,差异具有统计学意义(P<0.05);观察组患儿总有效率高于对照组,差异具有统计学意义(P<0.05);观察组患儿起病72 h内应用干扰素α–1b的总有效率高于对照组,差异具有统计学意义(P<0.05);观察组病毒阳性患儿的总有效率高于对照组病毒阳性患儿,差异具有统计学意义(P<0.05)。结论:早期采取雾化吸入干扰素α–1b,可减轻喘息性支气管肺炎患儿的临床症状,提高临床疗效,缩短住院时间,安全性良好。

Objective To study the clinical effect of atomization inhalation interferonα-1b in the treatment of children with asthmatic bronchopneumonia.Methods A total of 140 children with asthmatic bronchopneumonia admitted to Xinxiang Maternal and Child Health Hospital from September 2020 to December 2021 were randomly divided into an observation group and a control group,with 70 cases in each group.The control group was treated with budesonide and terbutaline atomization inhalation,and the observation group was treated with interferonα-1b atomization inhalation on the basis of the control group.The two groups were compared in terms of the duration of clinical symptoms and length of hospitalization time.After 7 days of treatment,the total efficacy of the two groups,the efficacy of treatment in the early and late stages of the disease,the efficacy of children with positive and negative respiratory virus test in the two groups,and the adverse events during the treatment were observed and compared.Results The fever,cough,wheezing,pulmonary rales and hospitalization time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of interferonα-1b in the observation group was higher than that in the control group within 72 hours of onset,and the difference was statistically significant(P<0.05).The total effective rate of virus positive children in the observation group was higher than that in the virus positive control group,and the difference was statistically significant(P<0.05).Conclusion Early use of atomization inhalation interferonα-1b can reduce the clinical symptoms of children with asthmatic bronchopneumonia,improve the clinical efficacy,shorten the length of hospitalization time,and has good safety.