贝那普利联合比索洛尔对高血压合并冠心病患者血压及心功能的影响

Effects of Benazepril Combined with Bisoprolol on Blood Pressure and Cardiac Function in Patients with Hypertension and Coronary Heart Disease

目的:探讨贝那普利联合比索洛尔对高血压合并冠心病患者血压及心功能的影响。方法:选取2020年1月至2022年8月在南阳市第一人民医院住院治疗的80例高血压合并冠心病患者,将患者随机分为对照组与观察组,每组40例。对照组治疗时应用贝那普利,观察组治疗时应用贝那普利联合比索洛尔,比较两组患者治疗前后的血压、血液流变学指标、心肌损伤指标、心功能指标、生活质量评分。结果:在治疗后,相比于对照组,观察组患者的收缩压、舒张压、各项血液流变学指标、各项心肌损伤指标、N末端B型利钠肽前体水平、Tei指数均更低,而左心射血分数、生活质量评分均更高,差异均具有统计学意义(P<0.05)。结论:贝那普利与比索洛尔联合治疗高血压合并冠心病的疗效良好,可有效控制患者血压,改善患者血液流变学及心功能指标,减轻心肌损伤,提升生活质量。

Objective To investigate the effect of benazepril combined with bisoprolol on blood pressure and cardiac function in patients with hypertension and coronary heart disease.Methods A total of 80 patients with hypertension and coronary heart disease who were hospitalized in Nanyang First People’s Hospital from January 2020 to August 2022 were selected and randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with benazepril,and the observation group was treated with benazepril combined with bisoprolol.The blood pressure,hemorheology index,myocardial injury index,cardiac function index,and quality of life score were compared between the two groups before and after treatment.Results After treatment,compared with the control group,the systolic blood pressure,diastolic blood pressure,hemorheological indexes,myocardial injury indexes,N-terminal pro-B-type natriuretic peptide level and Tei index in the observation group were lower,while the left ventricular ejection fraction and quality of life score were higher,and the differences were statistically significant(P<0.05).Conclusion Benazepril combined with bisoprolol is effective in the treatment of hypertension complicated with coronary heart disease,which can effectively control the blood pressure of patients,improve the hemorheology and cardiac function of patients,reduce myocardial injury,and improve the quality of life.