高压氧康复技术治疗创伤性脑损伤对患者应激反应及认知功能的影响

Effect of Hyperbaric Oxygen Rehabilitation on Stress Response and Cognitive Function of Patients with Traumatic Brain Injury

目的观察高压氧康复技术辅助治疗创伤性脑损伤的效果、对患者应激反应及认知功能的影响。方法选取2020年8月—2022年1月菏泽市立医院收治的创伤性脑损伤患者112例作为研究对象,经抽签法分为对照组(56例)与研究组(56例)。两组患者均先接受常规治疗,研究组联合应用高压氧康复技术治疗。使用功能独立性量表(FIM)评分以评估两组患者独立生活能力,使用神经行为认知量表(NCSE)评分以评估两组患者认知功能,使用酶联免疫吸附法检测丙二醛(MDA)、超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)等指标以评估两组患者应激反应情况,统计并对比两组的临床治愈率。结果干预前,两组患者FIM评分、NCSE评分以及氧化应激反应指标水平比较,差异无统计学意义(P>0.05)。干预后,研究组患者FIM、NCSE评分显著且大于对照组(P<0.05)。干预后,两组患者SOD和GSH-PX水平提高,MDA水平降低(P<0.05);研究组患者SOD、GSH-PX水平高于对照组,MDA水平低于对照组(P<0.05)。研究组临床治愈率高于对照组(P<0.05)。结论高压氧康复技术治疗创伤性脑损伤患者效果显著,能有效减轻患者应激反应,提高患者认知功能,值得临床应用。

Objective To observe the effect of hyperbaric oxygen rehabilitation technology on traumatic brain injury and its effect on patients’stress response and cognitive function.Methods 112 patients with traumatic brain injury admitted to Heze municipal hospital from August 2020 to January 2022 were selected and divided into the comparison group(56 cases)and the study group(56 cases)by drawing lots.The two groups of patients received routine treatment first.The study group was treated with hyperbaric oxygen rehabilitation technology.Functional independence scale(FIM)was used to evaluate their independent living ability,neurobehavioral cognitive scale(NCSE)was used to evaluate their cognitive function,and malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and other indicators were detected by enzyme immunoassay to evaluate their stress response.The clinical cure rates of the two groups were statistically analyzed and compared.Results Before intervention,there was no difference between the two groups in FIM score,NCSE score and oxidative stress response(P>0.05).After intervention,the FIM and NCSE scores of the study group were significantly higher than those of the control group(P<0.05).After intervention,the level of SOD and GSH-PX of the two groups were increased and the level of MDA of the two groups were decreased(P<0.05);the level of SOD,GSH-PX and MDA of the study group were higher than those of the control group(P<0.05).The clinical cure rate of the study group was higher than the control group(P<0.05).Conclusion Hyperbaric oxygen rehabilitation is effective in the treatment of traumatic brain injury,which can effectively reduce stress response and improve cognitive function of patients.