摘要
Despite intensive therapy regi men,brain cancers present with a poor prognosis,with an esti-mated median survival time of less than 15 months in case of glioblastoma.Early detection and improved surgical resctions are suggested to enhance prognosis;several tools are being explored to achieve the purpose.Raman spectroscopy(RS),a nondestructive and noninv asive technique,has been extensively explored in brain cancers.This review summarizes RS based studies in brain cancers,categorized into studies on animal models,ex tivo human samples,and in tito human subjects.Findings suggest RS as a promising tool which can aid in improving the accuracy of brain tumor surgery.Further adv ancements in instrumentation,market assessment,and clinical trials can facilitate translation of the technology as a noninvasive intraopenative guidance tool.
