基于全球专利的Bt抗虫基因研发态势分析与展望

Progress Analysis and Prospects of Bt Gene Research and Development Based on Global Patents

[目的/意义]通过对全球126个国家及地区的Bt抗虫基因专利进行统计分析,探究国内外主要研发机构Bt抗虫基因研发的进展和策略,借此为中国在Bt抗虫基因挖掘、产业化应用方面提供参考。[方法/过程]基于智慧芽全球专利数据库(PatSnap),利用专利分析法,对收录的有关Bt抗虫转基因的专利进行统计分析。从专利申请及公开趋势、基因类型、主要研发机构、技术研发热点领域等方面进行分析,研究全球Bt抗虫基因专利的技术现状、研发热点与未来发展态势。[结果/结论]全球Bt抗虫基因的研发趋势趋于稳定,中国在专利质量提升方面与国际先进仍有差距;跨国公司是Bt抗虫基因的市场竞争主体,融合基因和基因叠加的复合性状研究潜力巨大。

[Purpose/Significance]The huge economic benefits of Bt insect resistant genes have attracted great attention of relevant research institutions and enterprises at home and abroad,and these genes and technologies are transformed into their own exclusive rights by using intellectual property rights.Through statistical analysis of Bt insect resistant gene patents collected in 126 countries and regions around the world,this paper provides a reference for China in the development and industrial application of Bt insect resistant genes.[Method/Process]Based on the Global Patent Database of Smart Bud(PatSnap),the title,abstract and claim of the patent were taken as the focus of the search,and the patent analysis method was used to statistically analyze the Bt insect-resistant transgenic patents collected in the past 30 years since 1992.In the process of Bt anti-insect gene research,a large number of patent data were produced.After data cleaning,the"Bt strain","detection method","Bt insecticidal reagent"and other patents unrelated to the anti-insect gene were eliminated,and 2,988 patents were obtained,all of which were invention patents.The research status,research hotspots and development trends of global Bt pest resistance genes were studied from the aspects of total patent applications and trend,gene family classification,national/regional distribution,key technology fields,technology flow,institutional competitiveness,patent legalization status,and compound trait patents.[Results/Conclusions]Results show that the global Bt insect-resistant gene technology patent research and development trends,research hotspots and distribution technology gradually remain stable,the trend of patent application and disclosure in China is growing at the same time as that in the world.China’s patent applications account for an increasing proportion of the global patent applications.But compared with international patent quality,there is still a gap between China and other countries.Multinational companies are the main body of Bt pest resistance gene market competition,and Chinese applicants are mainly scientific research institutions and universities.The cry1 family is the main target of Bt pest resistance gene patent application.The crystallized protein of Bacillus is a hot topic at present.The United States is the exporting country of Bt insect-resistant gene technology,while China is still in the stage of technology input.The patent failure rate of Bt insect resistance gene is much lower than the average level in this field.There is great potential in the study of fusion genes and gene superposition composite traits.Finally,the development prospects of Bt insect resistance gene technology in China were discussed.