高胆红素血症对新生儿心肌酶谱及肾功能影响的研究

The Effect of Hyperbilirubinemia on Myocardial Zymogram and Renal Function in Neonates

目的研究高胆红素血症对新生儿心肌酶谱血清学、肾功能水平的影响。方法选取我院收治的80例高胆红素血症足月新生儿作为观察对象,根据不同胆红素水平分为轻度组40例(220.6~256.5μmol/L)及中重度组40例(≥256.6μmol/L),同时选取30例高危儿作为对照组,比较其心肌酶谱、肾功能、心电图及心脏彩超等结果。结果观察组心肌酶谱及肾功能指标胱抑素C水平均高于对照组,差异具有统计学意义(P<0.05)。结论不同水平胆红素对高胆红素血症新生儿肾功能、心肌损伤标志物水平存在不同程度的影响,胆红素水平越高,心肌及肾脏受损程度越严重。

Objective To study the effect of hyperbilirubinemia on serum myocardial zymogram and renal function in neonates.Methods 80 full-term neonates with hyperbilirubinemia were selected and assigned into mild group(n=40,220.6~256.5μmol/L)and moderate-severe group(n=40,≥256.6μmol/L)according to different levels of bilirubin.At the same time,30 high-risk infants were designed into the control group.The results of myocardial zymogram,renal function,electrocardiogram and Doppler echocardiography were compared.Results The levels of myocardial zymogram and renal function index cystatin C in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Different levels of bilirubin have different effects on renal function and myocardial damage markers in neonates with hyperbilirubinemia.The higher the level of bilirubin,the more serious the damage of myocardium and kidney.