CRISPR-Cas12a在疾病诊断和中医药研究中的应用

Application of CRISPR-Cas12a in disease diagnosis and traditional Chinses medicine research

介绍CRISPR-Cas12a的结构及功能。概述CRISPR-Cas12a系统的附属切割活性在疾病诊断(病毒性疾病、细菌感染性疾病、肿瘤)中的应用,简述其检测方法及原理。对CRISPR-Cas12a在中医药防治疾病研究中的应用,中药材种植、中药材品种鉴定和质量控制中的潜在应用进行展望。

To describe the structure and function of CRISPR-Cas12a.The application of the collateral cleaving activity of the CRISPR-Cas12a system in disease diagnosis(viral diseases,bacterial infectious diseases,and tumors)is summarized,and the detection methods as well as their principles are briefly described.The application of CRISPR-Cas12a in traditional Chinses medicine(TCM)is prospected,mainly including in the TCM research of prevention and treatment of diseases,the cultivation,the identification and quality control of TCM plants.