中国成年人群前期糖尿病患者血清25羟维生素D水平与抑郁症状的关联性研究

ASSOCIATION BETWEEN SERUM LEVEL OF 25-HYDROXYL VITAMIN D AND DEPRESSIVE SYMPTOMS IN CHINESE ADULTS WITH PREDIABETES

目的 血清25羟维生素D[25(OH)D]水平与抑郁症状以及前期糖尿病有关。但关于患有前期糖尿病和血清25(OH)D浓度较低的个体,其出现抑郁症状风险增加的相关证据有限。此外,尚未证实这种可能的关联是否发生在中国人群中。本研究旨在确定中国前期糖尿病患者的血清25(OH)D水平与抑郁症状的关联。方法 本次研究为横断面研究,以天津人群慢性低度系统性炎症与健康队列的成年人群为研究对象(n=4051)。使用抑郁自评量表(SDS)(截断值SDS≥45)评估抑郁症状。血清25(OH)D浓度通过IDS 25(OH)D EIA试剂盒测量。血清25(OH)D浓度分为三个等级:等级1:<50nmol/L,等级2:50-75nmol/L,等级3:>75nmol/L。依据美国糖尿病协会的标准将前期糖尿病定义为空腹血糖(IFG)受损、糖耐量(IGT)受损、糖化血红蛋白(IA1c)受损。在调整混杂因素后,采用多元Logistic回归评估血清25(OH)D浓度水平与前期糖尿病患者抑郁症状之间的关联。结果 本研究总人群中,有14.2%的人群有抑郁症状(SDS≥45)。在对潜在混杂因素进行调整后,男性血清25(OH)D各水平的抑郁症状比值比(95%置信区间)分别为1.00、1.03(0.77,1.36)和0.92(0.59,1.40)。女性的比值比(95%置信区间)分别为1.00、1.03 (0.57,1.39)和0.28(0.12,0.57)。结论 我们观察到中国女性前期糖尿病患者的血清25(OH)D水平与抑郁症状之间存在显着的负相关。这种低25(OH)D浓度与加重的抑郁症状间的关联表明维生素D缺乏可能是晚年患抑郁症的危险因素。[营养学报,2022,44(5):455-462]

Objective Serum level of 25-hydroxyl vitamin D[25(OH)D]had been associated with depressive symptoms and prediabetes.Evidence for the increased risk of depressive symptoms in individuals with prediabetes and a low vitamin D status was limited.Furthermore,it had not been confirmed whether this possible relationship occurs in the Chinese population.The aim of this study was to determine the association of vitamin D status (25-hydroxyl vitamin D,25(OH)D)with depressive symptoms in Chinese adults with prediabetes.Methods This was a cross-sectional study of 4,051 adults in Tianjin,China.Depressive symptoms were assessed using the Self-Rating Depression Scale (SDS)(cut-off point SDS≥45).Serum 25(OH)D concentrations were measured by the IDS 25(OH)D EIA kit.Serum 25(OH)D concentration was divided three levels:level 1<50nmol/L,level 2:50–75nmol/L,level 3>75nmol/L.Prediabetes was defined as impaired fasting glucose (IFG),impaired glucose tolerance (IGT),impaired HbA1c (IA1c) based on the American Diabetes Association criteria.Multiple logistics regression analysis was conducted to assess the associated between serum 25(OH)D concentration level and depressive symptoms in prediabetes.A number of potential confounders were adjusted in the models.Results In this study,14.2%had depressive symptoms (SDS≥45).After adjustments for potentially confounding factors,the ORs (95%CI) for depressive symptoms across serum 25(OH)D levels in men were 1.00,1.03 (0.77,1.36) and 0.92 (0.59,1.40).In contrast,in women,(95%CI) was 1.00,1.03 (0.57,1.39),0.28 (0.12,0.57).Conclusion We observed a significant negative association between serum level of 25(OH)D and depressive symptoms in Chinese women with prediabetes.Association found between low 25(OH)D levels and elevated depressive symptoms suggested that vitamin D deficiency may be a risk factor for late-life depression.[ACTA NUTRIMENTA SINICA,2022,44 (5):455-462]