清火退热口服液辅助治疗小儿支原体肺炎痰热闭肺证的疗效及对血清超敏C-反应蛋白和免疫功能的影响

Efficacy of QinghuoTuire Koufuye(清火退热口服液)in adjuvant treatment of mycoplasma pneumonia in children with phlegm-heat obstructing lung syndrome and its effect on serum high?sensitivity C?reactive protein and immune function

目的观察清火退热口服液辅助治疗小儿支原体肺炎(mycoplasma pneumonia,MPP)痰热闭肺证的临床疗效及对血清超敏C-反应蛋白(hs-CRP)和免疫功能的影响。方法选取2018年8月至2019年10月在丽水市中医医院儿科就诊的MPP痰热闭肺证患儿130例,采用随机数字表法分为对照组和治疗组,各65例。对照组给予西医常规对症治疗,治疗组在对照组治疗方法的基础上予清火退热口服液,2组均1周为1个疗程,治疗2个疗程后统计临床疗效。结果治疗组总有效率为98.46%(64/65),明显高于对照组的89.23%(58/65),2组比较,差异有统计学意义(P<0.05)。2组治疗前CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平明显升高,CD8^(+)水平明显降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组升高或降低更显著(P<0.05)。2组治疗前血清IgA、IgG、IgM水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组血清IgA、IgM水平明显降低,IgG水平明显升高,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组降低或升高更显著(P<0.05)。2组治疗前血清超敏C-反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组血清hs-CRP水平均明显降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。结论清火退热口服液辅助治疗小儿MPP痰热闭肺证,不仅能调整机体的体液免疫、细胞免疫功能,抑制炎性反应,而且疗效显著,值得临床推广应用。

Objective To observe the clinical efficacy of Qinghuo Tuire Koufuye(清火退热口服液)in the adjuvant treatment of mycoplasma pneumonia(MPP)with phlegm-heat obstructing lung syndrome and its effect on serum high-sensitivity C-reactive protein(hs-CRP)and immune function.Methods 130 children with MPP who were treated in Lishui Hospital of TCM between August 2018 and October 2019 were selected and divided equally into in control group and treatment group using a random number table.The control group was given routine symptomatic treatment of Western medicine,and the treatment group was given Qinghuo Tuire Koufuye on the basis of the remedy of the control group.Both groups were treated for 1 week as a course of treatment,and we kept statistics about the two groups before and after 2 courses of treatment.Results The total effective rate of the treatment group was 98.46%(64/65),which was significantly higher than 89.23%(58/65)of the control group.The difference between the two groups was statistically significant(P<0.05).There was no significant difference in the levels of CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)between the two groups before treatment(P>0.05),indicating that they were comparable.After treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the two groups were significantly increased,and the level of CD8^(+)was decreased significantly,and the differences were statistically significant in the same group(P<0.05),and the increase or decrease in the treatment group was more significant(P<0.05).There was no significant difference in the levels of IgA,IgG and IgM of serum between the two groups before treatment(P>0.05),indicating that they were comparable.After treatment,the levels of IgA and IgM in the two groups were decreased significantly,meanwhile,the level of IgG was increased significantly,the difference was statistically significant in the same group(P<0.05),and the decrease or increase in the treatment group was more significant(P<0.05).There was no significant difference in the level of hs-CRP between the two groups before treatment(P>0.05),which was comparable.After treatment,the serum hs-CRP levels in the two groups were decreased significantly,the difference was statistically significant in the same group(P<0.05),and the decrease in the treatment group was more significant(P<0.05).Conclusion Qinghuo Tuire Koufuye in the adjuvant treatment of MPP with phlegm-heat obstructing lung syndrome in children can not only adjust the body’s humoral immunity and cellular immune function,inhibit inflammatory response,but also has a significant effect,which is worthy of clinical application.