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和中健脾汤联合饮食运动疗法治疗儿童单纯性肥胖脾虚湿阻证43例临床观察 被引量:2

Clinical observation on 43 cases of simple obesity in children with dampness obstruction due to spleen?asthenia syndrome treated by Hezhong Jianpi Tang(和中健脾汤)combined with dietary and exercise therapy
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摘要 目的观察和中健脾汤联合饮食运动疗法治疗儿童单纯性肥胖脾虚湿阻证的临床疗效。方法选取2020年7月至2021年4月在杭州市拱墅区中西医结合医院儿保科门诊诊治的单纯性肥胖脾虚湿阻证患儿86例,采用随机数字表法分为对照组和治疗组,各43例。对照组予以饮食运动疗法,治疗组在对照组治疗方法的基础上予和中健脾汤,2组均治疗12周后统计疗效。结果治疗组总有效率为90.70%(39/43),显著高于对照组的72.09%(31/43),2组比较,差异有统计学意义(P<0.05)。治疗前,2组脂肪因子血清胰高血糖素样肽(GLP-2)、脂联素(APN)、脂质运载蛋白2(LCN2)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述脂肪因子水平较同组治疗前显著降低或升高(P<0.05),且治疗组降低或升高更显著,差异有统计学意义(P<0.05)。治疗组不良反应总发生率为9.31%(4/43),对照组为4.66%(2/43),2组比较,差异无统计学意义(P>0.05)。结论和中健脾汤联合饮食运动疗法治疗儿童单纯性肥胖脾虚湿阻证,疗效满意,不仅能明显改善血清脂肪因子水平,而且不良反应少,值得临床推广应用。 Objective To observe the clinical efficacy of Hezhong Jianpi Tang(和中健脾汤)combined with dietary and exercise therapy for simple obesity in children with dampness obstruction due to spleen-asthenia syndrome.Methods From July 2020 to April 2021,86 cases of simple obesity in children with dampness obstruction due to spleen-asthenia syndrome diagnostically treated in Department of Children Healthcare of Gongshu District Integrated Traditional Chinese and Western Medicine Hospital in Hangzhou were divided into control group and treatment group according to random number table method,with 43 cases in each group.The control group was given dietary and exercise therapy,on this basis,the treatment group was given Hezhong Jianpi Tang.The clinical efficacy was assessed after the 2 groups were both treated for 12 weeks.Results The total effective rate of the treatment group was 90.70%(39/42),which was significantly higher than 72.09%(31/43)of the control group,and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,the differences were not statistically significant in serum adipokine levels of glucagon-like peptide 2(GLP-2),adiponectin(APN)and lipocalin 2(LCN2)between the two groups(P>0.05),indicating comparability.After treatment,the above-mentioned adipokine levels in the 2 groups significantly decreased/increased as compared with the same group before treatment(P<0.05),moreover,the decrease/increase was more significant in the treatment group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the treatment group was 9.31%(4/43),that of the control group was 4.66%(2/43),and the difference was not statistically significant between the 2 groups(P>0.05).Conclusion It has satisfactory efficacy to use Hezhong Jianpi Tang combined with dietary and exercise therapy for simple obesity in children with dampness obstruction due to spleen-asthenia syndrome,which can not only alleviate serum adipokine levels markedly,but also has less adverse reactions.It deserves clinical promotion and application.
作者 刘蓉 LIU Rong(Department of Children Healthcare,Gongshu District Integrated Traditional Chinese and Western Medicine Hospital in Hangzhou,Hangzhou,Zhejiang,310011,China)
出处 《中医儿科杂志》 2022年第6期74-77,共4页 Journal of Pediatrics of Traditional Chinese Medicine
关键词 单纯性肥胖 儿童 脾虚湿阻证 和中健脾汤 饮食运动疗法 临床观察 simple obesity children dampness obstruction due to spleen-asthenia syndrome Hezhong Jianpi Tang(和中健脾汤) dietary and exercise therapy clinical observation
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