摘要
1型糖尿病(T1DM)是儿童和青少年常见的以胰岛β细胞破坏和胰岛素缺乏为特征的自身免疫性疾病。近期研究表明,肠道菌群失衡和肠黏膜屏障变化与T1DM发生发展相关,但具体机制尚不清楚。本文就近年肠道菌群、肠黏膜屏障在T1DM中的作用研究进行综述,并探讨孕期治疗、粪菌移植、益生菌、短链脂肪酸治疗维持健康肠黏膜屏障改善T1DM的研究进展,为T1DM防治提供新方法。
Type 1 diabetes(T1DM)is a common autoimmune disease in children and adolescents characterized by destruction of isletβ-cells and lack of insulin.Recent studies have shown that imbalance of intestinal flora and changes in intestinal mucosal barrier are related to occurrence and development of T1DM,but exact mechanism is still unclear.This article reviews recent studies on intestinal flora and intestinal mucosal barrier in T1DM,and discusses current research status of improving T1DM by treatment during pregnancy,fecal bacteria transplantation,probiotics,and short-chain fatty acid therapy to maintain healthy intestinal mucosal barrier,to provide new ideas and methods for prevention and treatment of T1DM.
作者
宋超杰
张小莉(指导)
陈换换
唐聪
SONG Chaojie;ZHANG Xiaoli;CHEN Huanhuan;TANG Cong(Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2022年第24期3053-3057,3062,共6页
Chinese Journal of Immunology
基金
河南省科技攻关项目(172102310091)
河南省高等学校重点科研项目(20B310005)资助。
关键词
1型糖尿病
肠黏膜屏障
肠道菌群
防治
Diabetes mellitus type 1
Intestinal mucosal barrier
Intestinal flora
Preventive treatment
