摘要
An unprecedented difluorocarbene-mediated C-O bond cleavage of cyclic ethers for the construction of difluoromethyl ethers is herein disclosed.This protocol is distinguished by its mild conditions,high efficiency,and wide substrate scope,which can tolerate both sensitive functional groups such as the hydroxyl group,olefin and C-C triple bonds,as well as complex molecules.It thus demonstrates excellent chemoselectivities and great potential for late-stage modification of pharmaceutical compounds and natural products.It is worth noting that this method not only introduces fluorine atoms into the final molecules,but it can also effectively form an ester or ether linkage.
基金
Financial support by the National Natural Science Foundation of China(grant no.21931013)and the Open Research Fund of the School of Chemistry and Chemical Engineering,Henan Normal University is gratefully acknowledged.The authors also thank the Instrumental Analysis Center of Huaqiao University for analysis support.
