机体抗病毒过程中细胞凋亡的研究进展

Research progress of apoptosis in process of anti-virus

病毒是一种传染性实体,可利用细胞生物合成机器复制自身核酸并合成由其核酸编码的蛋白,装配成完整、有感染性的病毒粒。多数情况下,病毒可导致疾病,甚至会导致被感染宿主死亡。细胞凋亡贯穿于机体整个生命活动过程,在防卫病毒感染中起重要作用。当病毒引起宿主细胞凋亡时,通过免疫细胞吞噬和消化清除未成熟的病毒粒,但病毒为了生存与扩散会抑制细胞凋亡。本文将对细胞凋亡在机体抗病毒作用的相关研究进行综述,以期为病毒感染诊断和治疗提供新思路。

Viruses are infectious entities that can use machinery and metabolism of a host cell to replicate its nucleic acids and synthesize proteins encoded by its nucleic acids,and finally assembly infectious virions. In most cases,virus can cause diseases and even cause infected host to death. Apoptosis runs through whole life process of the body and plays an important role in host defense against virus infection. When virus causes apoptosis in host cell,it will be phagocytosed and digested by immune cells,thereby clearing immature virions. But virus will also inhibit apoptosis in order to survive and spread in many ways. This article will review related research on roles of apoptosis in host against virus,in order to provide more ideas for diagnosis and treatment of viral infection.