淡竹叶黄酮类成分的研究

Flavonoids from Lophatherum gracile

目的研究淡竹叶Lophatherum gracile Brongn.黄酮类成分。方法淡竹叶提取物采用ODS、MCI、Sephadex LH-20进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到20个化合物,分别鉴定为芦丁(1)、槲皮素(2)、槲皮素-3-O-β-D-葡萄糖苷(3)、槲皮素-7-O-α-L-鼠李糖-3-O-β-D-芸香糖苷(4)、槲皮素-3-O-β-D-葡萄糖-(1-6)-O-α-L-鼠李糖-(1-2)-O-β-D-木糖糖苷(5)、槲皮素-3-O-β-D-葡萄糖-(1-2)-O-α-L-鼠李糖-(1-6)-O-β-D-葡萄糖-(1-2)-O-α-L-鼠李糖糖苷(6)、山柰酚(7)、山柰酚-3-O-β-D-芸香糖苷(8)、异鼠李素(9)、异鼠李素-3-O-β-D-芸香糖苷(10)、异鼠李素-3-O-β-D-芸香糖-(2-1)-O-β-D-葡萄糖苷(11)、异鼠李素-7-O-α-L-吡喃鼠李糖-3-O-β-D-芸香糖苷(12)、异鼠李素-3-O-β-D-葡萄糖苷(13)、异鼠李素-3-O-β-D-葡萄糖苷-1-烯-4-羰基-十二烷基(14)、5,7,4′-三羟基-6′-甲氧基-异黄酮(15)、5,7,4′-三羟基异黄酮(16)、5,7,3′-三羟基-4′-甲氧基异黄酮(17)、7-羟基-4′-甲氧基异黄酮(18)、5,4′-二羟基异黄酮-1″-烯-5″-酮-十二烷基(19)、5,3′,4′-三羟基异黄酮-7-O-β-D-芸香糖苷(20)。结论化合物5、6、15~20为首次从淡竹叶属植物中分离得到。

AIM To study the flavonoids from Lophatherum gracile Brongn.METHODS The extract from L.gracile was isolated and purified by ODS,MCI,Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twenty compounds were isolated and identified as rutin(1),quercetin(2),quercetin-3-O-β-D-glucoside(3),quercetin-7-O-α-L-rhamnose-3-O-β-D-rutinoside(4),quercetin-3-O-β-D-glucose-(1-6)-O-α-L-rhamnose-(1-2)-O-β-D-xyloside(5),quercetin-3-O-β-D-glucose-(1-2)-O-α-L-rhamnose-(1-6)-O-β-D-glucose-(1-2)-O-α-L-rhamnoside(6),kaempferol(7),kaempferol-3-O-β-D-rutinoside(8),isorhamnetin(9),isorhamnetin-3-O-β-D-rutinoside(10),isorhamnetin-3-O-β-D-rutose-(2-1)-O-β-D-glucoside(11),isorhamnose-7-O-α-L-rhamnose-3-O-β-D-rutinoside(12),isorhamnetin-3-O-β-D-glucoside(13),isorhamnetin-3-O-β-D-glucoside-1-ene-4-carbonyl-dodecyl(14),5,7,4′-trihydroxy-6′-methoxy-isoflavone(15),5,7,4′-trihydroxyisoflavone(16),5,7,3′-trihydroxy-4′-methoxyisoflavone(17),7-hydroxy-4′-methoxyisoflavone(18),5,4′-dihydroxyisoflavone-1″-en-5″-one-dodecyl(19),5,3′,4′-trihydroxyisoflavone-7-O-β-D-rutinoside(20).CONCLUSION Compounds 5,6,15-20 are first isolated from genus Lophantherum.