蒙古莸化学成分的研究

Chemical constituents from Caryopteris mongholica

目的研究蒙古莸Caryopteris mongholica Bunge的化学成分。方法蒙古莸95%乙醇提取物采用硅胶柱、薄层色谱和高效液相色谱进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到13个化合物,分别鉴定为royleanone(1)、6,7-didehydroferruginol(2)、11β-hydroxy-8,(9),15-isopimaren-7-one(3)、(16 S)-12,16-epoxy-11,14-dihydroxy-17(15→16)-abeo-abieta-8,11,13-trien-7-one(4)、demethylcryptojaponol(5)、6α-hydroxydemethylcryptojaponol(6)、incanone(7)、3β-乙酰基齐墩果酸(8)、香草酸(9)、麦芽酚(10)、曲酸(11)、3,5-dihydroxy-2-hydroxymethyl-4 H-pyran-4-one(12)、植醇(13)。结论化合物1~3、7~13为首次从莸属植物中分离得到。

AIM To study the chemical constituents from Caryopteris mongholica Bunge.METHODS The 95%ethanol extract from C.mongholica was isolated and purified by silica gel column chromatography,thin layer chromatography,high performance liquid chromatography,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Thirteen compounds were isolated and identified as royleanone(1),6,7-didehydroferruginol(2),11β-hydroxy-8,(9),15-isopimaren-7-one(3),(16 S)-12,16-epoxy-11,14-dihydroxy-17(15→16)-abeo-abieta-8,11,13-trien-7-one(4),demethylcryptojaponol(5),6α-hydroxydemethylcryptojaponol(6),incanone(7),3β-acetyl oleanolic acid(8),vanillic acid(9),maltol(10),kojic acid(11),3,5-dihydroxy-2-hydroxymethyl-4 H-pyran-4-one(12),phytol(13).CONCLUSION Compounds 1-3,7-13 are isolated from genus Caryopteris for the first time.