摘要
目的研究蒙古莸Caryopteris mongholica Bunge的化学成分。方法蒙古莸95%乙醇提取物采用硅胶柱、薄层色谱和高效液相色谱进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到13个化合物,分别鉴定为royleanone(1)、6,7-didehydroferruginol(2)、11β-hydroxy-8,(9),15-isopimaren-7-one(3)、(16 S)-12,16-epoxy-11,14-dihydroxy-17(15→16)-abeo-abieta-8,11,13-trien-7-one(4)、demethylcryptojaponol(5)、6α-hydroxydemethylcryptojaponol(6)、incanone(7)、3β-乙酰基齐墩果酸(8)、香草酸(9)、麦芽酚(10)、曲酸(11)、3,5-dihydroxy-2-hydroxymethyl-4 H-pyran-4-one(12)、植醇(13)。结论化合物1~3、7~13为首次从莸属植物中分离得到。
AIM To study the chemical constituents from Caryopteris mongholica Bunge.METHODS The 95%ethanol extract from C.mongholica was isolated and purified by silica gel column chromatography,thin layer chromatography,high performance liquid chromatography,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Thirteen compounds were isolated and identified as royleanone(1),6,7-didehydroferruginol(2),11β-hydroxy-8,(9),15-isopimaren-7-one(3),(16 S)-12,16-epoxy-11,14-dihydroxy-17(15→16)-abeo-abieta-8,11,13-trien-7-one(4),demethylcryptojaponol(5),6α-hydroxydemethylcryptojaponol(6),incanone(7),3β-acetyl oleanolic acid(8),vanillic acid(9),maltol(10),kojic acid(11),3,5-dihydroxy-2-hydroxymethyl-4 H-pyran-4-one(12),phytol(13).CONCLUSION Compounds 1-3,7-13 are isolated from genus Caryopteris for the first time.
作者
代那音台
王青虎
白梅荣
邰巴达拉胡
娜布其
赵雨
Dai-na-yin-tai;WANG Qing-hu;BAI Mei-rong;Tai-ba-da-la-hu;Na-bu-qi;ZHAO Yu(Jilin Ginseng Academy,Changchun University of Chinese Medicine,Changchun 130000,China;Ministry of Education Key Laboratory for Mongolian Medicine Research and Development,College of Traditional Mongolian Medicine,Inner Mongolia Minzu University,Tongliao 028000,China)
出处
《中成药》
CAS
CSCD
北大核心
2023年第1期119-123,共5页
Chinese Traditional Patent Medicine
基金
内蒙古自治区高等学校科学研究项目(NJZY22457)
蒙医药研发工程教育部重点实验室开放课题(MDK2020020)。
关键词
蒙古莸
化学成分
分离鉴定
Caryopteris mongholica Bunge
chemical constituents
isolation and identification