晚期糖基化终末产物与结核病的关系研究进展

Research Progress on the Relationship Between Advanced Glycation End Products and Tuberculosis

糖尿病是结核病易感性和再活化的主要危险因素之一。晚期糖基化终末产物(Advanced glycation end products, AGEs)是糖和蛋白质、脂质、核酸等大分子物质发生非酶促反应而形成的一种异质物,病理状态下血糖异常升高可促进其生成。最近的研究表明,AGEs通过对巨噬细胞的影响、炎症反应及氧化应激等多种机制,在结核分枝杆菌感染和结核病进展中发挥了作用。因而,AGEs是结核病发病机制的参与者,可成为辅助结核病治疗的一个新靶标。

Diabetes mellitus is one of the main risk factors of tuberculosis susceptibility and reactivation.Advanced glycation end products(AGEs)is a kind of Heterogeneity formed by non enzymatic reaction between sugar and macromolecular substances such as protein, lipid and nucleic acid, which can be promoted to form by abnormal increase of blood glucose in the pathological state.Recent studies have shown that AGEs plays an important role in Mycobacterium tuberculosis infection and the progression of tuberculosis through multiple mechanisms such as the effect on macrophage, inflammatory response and oxidative stress.Therefore, AGEs is a participant in the pathogenesis of tuberculosis and a new target of TB adjuvant treatment.