肠道-大脑-微生物群轴在卒中后抑郁的研究进展

Research progress of gut-brain-microbiota axis in post-stroke depression

卒中后抑郁是脑卒中后最常见的神经、精神并发症之一,既往药物治疗的安全性及疗效不确定性往往造成患者病情迁延,严重影响患者生活质量。随着肠道微生物群对肠-脑轴独特的调节作用被发现,卒中后抑郁的预防及治疗有了新的突破,即肠道微生物群可以通过神经内分泌、免疫、代谢系统等通路调节肠-脑轴形成正负反馈,让患者获得神经及肠道保护益处,使其在卒中后抑郁的预防及治疗中发挥出精准的调节作用。本文尝试总结肠道微生物群与肠-脑轴之间的相互作用机制,与卒中后抑郁的相关性,治疗上的新方法与干预措施及其机制。为卒中后抑郁的预防、治疗提供新思路。

Post-stroke depression is one of the most common neurological and mental symptoms after stroke, the unsafe and inaccurate efficacy of drug treatment in the past, often results in patients with prolonged disease, which seriously affects the quality of life of patients. The discovery of the unique regulation of gut microbiota on the gut-brain axis provides a breakthrough for the prevention and treatment of post-stroke depression. The gut microbiota can regulate the gut-brain axis through neuroendocrine, immune and metabolic system pathways to form positive and negative feedback, allowing patients to obtain neuro-and gut-protective benefits, allowing them to play a precise regulatory role in the prevention and treatment of post-stroke depression. This paper attempts to summarize the interaction mechanism between gut microbiota and the gut-brain axis, the correlation between intestinal microbiota and post-stroke depression, new methods and interventions in the treatment, and their mechanism. To provide new ideas for the prevention, and treatment of post-stroke depression.