介孔二氧化硅纳米粒在药物输送领域中的应用

Application of mesoporous silica nanoparticles in drug delivery

介孔二氧化硅纳米粒具有有序的介孔结构、比表面积大、表面易于修饰及较高的胶体稳定性,在药物靶向治疗和控缓释领域受到越来越多的关注。作为药物载体,未经修饰的介孔二氧化硅具有比较明显的“突释”作用,通过在其表面修饰有机小分子、无机纳米粒子及环状分子等可有效提高药物释放效率,有利于改善体系稳定性和生物相容性,促进介孔二氧化硅纳米粒在药物输送领域的进一步应用。

Mesoporous silica nanoparticles with ordered mesoporous structure, large specific surface area, easy surface modification, and high colloidal stability have attracted more and more attention in the field of drug targeted therapy and controlled-release. As a drug carrier, unmodified mesoporous silica has a relatively obvious “sudden release”effect, by modifying small organic molecules, inorganic nanoparticles, and ring molecules on its surface, the drug release efficiency can be effectively improved, which is beneficial to improve the stability and biocompatibility of the system, and promote the further application of mesoporous silica nanoparticles in the field of drug delivery.