甲泼尼龙耳后局部注射对低频下降型突发性聋的效果及血液流变学和安全性的影响

Effect and influence of hemorheology and safety of Methylprednisolone local injection behind the ear in patients with low frequency descending sudden deafness

目的探究甲泼尼龙耳后局部注射对低频下降型突发性聋的效果及血液流变学和安全性的影响。方法选取2016年11月至2021年11月南京医科大学附属淮安第一医院收治的93例低频下降型突发性聋患者,采用随机数字表法将其分为对照组(47例,采用甲泼尼龙静脉滴注)与观察组(46例,采用甲泼尼龙耳后注射),两组疗程均为14 d。检测并比较治疗前后两组听阈,统计两组临床疗效。治疗前后检测并比较两组血液流变学指标与血浆同型半胱氨酸(Hcy)水平,统计治疗期间不良反应的发生情况。结果治疗后,两组听阈低于治疗前(P<0.05)。观察组疗效优于对照组(P<0.05)。治疗后,两组血浆黏度、全血高切黏度、全血低切黏度、Hcy水平均低于治疗前,且观察组低于对照组(P<0.05)。观察组不良反应总发生率低于对照组(P<0.05)。结论对低频下降型突发性聋患者耳后局部注射甲泼尼龙疗效显著,可以改善患者血液流变学指标,降低不良反应发生情况,建议临床推广使用。

Objective To investigate the effect and influence of hemorheology and safety of Methylprednisolone local injection behind the ear injection in patients with low frequency descending sudden deafness.Methods A total of 93 patients with low-frequency descending sudden deafness admitted to Huaian First Hospital Affiliated to Nanjing Medical University from November 2016 to November 2021 were selected and divided into control group(47 patients receiving Methylprednisolone intravenous infusion)and observation group(46 patients receiving Methylprednisolone local injection behind the ear)by random number table method.The course of treatment in both groups was 14 days.The auditory threshold of the two groups before and after treatment was detected and compared,and the clinical efficacy of the two groups was analyzed.The hemorheology indexes and plasma homocysteine(Hcy)levels of the two groups were detected and compared before and after treatment,and the occurrence of adverse reactions during treatment were analyzed.Results After treatment,the hearing threshold in both groups was lower than that before treatment(P<0.05).The curative effect of the observation group was better than that of the control group(P<0.05).After treatment,plasma viscosity,whole blood high tangential viscosity,whole blood low tangential viscosity,and Hcy levels in two groups were lower than those before treatment,and observation group was lower than control group(P<0.05).The total incidence of adverse reactions in observation group was lower than that in control group(P<0.05).Conclusion The Methylprednone local injection behind the ear in patients with low frequency descending sudden deafness has significant effect,which can improve the hemorheology index of patients and reduce the occurrence of adverse reactions,so it is recommended to be widely used in clinic.