不同来源外泌体在骨质疏松中的研究进展

Research progress of exosomes from different sources in osteoporosis

骨质疏松症是骨代谢异常导致的常见病,成骨形成减少、破骨吸收增强是其主要的机制。近年来大量研究发现,不同来源外泌体通过自身或协同作用,在成骨形成和增殖、破骨分化和吸收、骨微结构的重塑和骨矿化、肿瘤分期和转移及骨微环境中扮演着重要的角色,尤其是在骨质疏松的领域。不同来源外泌体通过其内的mi RNA,经成骨或破骨代谢通路,作用于靶细胞影响骨代谢,参与了抗骨质疏松治疗及疾病的微观解释。因此,本文就不同来源外泌体在骨质疏松中的研究进展进行综述,旨在为临床治疗骨质疏松提供新的研究方向。

Osteoporosis is the common disease caused by abnormal bone metabolism,and its main mechanism is reduced osteogenesis and enhanced osteoclast absorption.In recent years,a large number of studies have found that exosomes from different sources play an important role in osteoblast formation and proliferation,osteoclast differentiation and absorption,remodeling of bone microstructure and bone mineralization,tumor staging and metastasis,and bone microenvironment,especially in the field of osteoporosis,through their own or synergistic actions.Exosomes from different sources affect bone metabolism of target cells through osteogenic or osteoclastic metabolic pathways through mi RNA in exosomes,and participate in the treatment of anti-osteoporosis and microinterpretation of diseases.Therefore,this article reviews the research progress of exosomes from different sources in osteoporosis,aiming to provide a new research direction for clinical treatment of osteoporosis.