子宫内膜癌分子分型检测的研究进展

Research progress on molecular typing detection of endometrial cancer

子宫内膜癌(EC)严重威胁女性的身体健康,近些年来,随着经济、环境等众多因素的影响,EC逐渐朝着发病率升高、年轻化的趋势发展,已经超过宫颈癌、卵巢癌成为一些欧洲发达国家发病率最高的妇科恶性肿瘤。目前临床对肿瘤的各项研究已迈入了分子分型时代,这与分子生物学技术研究的快速发展密不可分。本文将综述当前子宫内膜癌分类系统中的挑战,定义预测不同分子亚型的新分子技术的发展及分子分型的潜在应用。

Endometrial cancer(EC) is a serious threat to women’s health.In recent years,with the influence of many factors such as economy and environment,EC is gradually developing towards higher incidence and younger trend,and has surpassed cervical cancer and ovarian cancer to become gynecological malignancy with the highest incidence rate in some developed European countries.At present,clinical studies on tumor have entered the age of molecular typing,which is closely related to the rapid development of molecular biological technology research.This paper reviews the challenges in the current classification system of endometrial carcinoma,the development of new molecular techniques to define and predict different molecular subtypes,and the potential applications of molecular typing.