自噬相关蛋白Beclin1在食管鳞癌中表达特点及临床意义的meta分析

Meta-analysis of the expression characteristics and clinical significance of autophagy related protein Beclin1 in esophageal squamous cell carcinoma

目的对自噬相关蛋白Beclin1在食管鳞癌(ESCC)中表达特点及临床意义进行系统评价。方法计算机检索建库至2021年12月Pub Med、Web of Science、中国知网、万方数据库、维普网中有关Beclin1在ESCC中表达特点及其与临床病理特征关系的文献,采用Rev Man 5.4进行meta分析。结果共纳入13项研究,包括ESCC患者1080例。meta分析结果显示,ESCC组Beclin1表达低于对照组(OR=0.09,95%CI:0.05~0.17,P<0.00001);高、中分化ESCC患者Beclin1表达高于低分化患者(OR=2.01,95%CI:1.49~2.72,P<0.00001);TNM分期Ⅰ~Ⅱ期ESCC患者Beclin1表达高于Ⅲ~Ⅳ期患者(OR=2.78,95%CI:1.76~4.41,P<0.0001);浸润深度为T_(1)~T_(2)期ESCC患者Beclin1表达高于T_(3)~T_(4)期患者(OR=2.16,95%CI:1.58~2.97,P<0.00001);无淋巴结转移ESCC患者Beclin1表达高于发生淋巴结转移的患者(OR=0.26,95%CI:0.14~0.49,P<0.0001)。结论Beclin1表达与ESCC临床病理特征密切相关,Beclin1可能是参与ESCC发生发展过程中的重要靶点。

Objective To systematically evaluate the expression characteristics and clinical significance of autophagy related protein Beclin1 in esophageal squamous cell carcinoma(ESCC).Methods The literatures of expression characteristics of Beclin1 in ESCC and its relationship with clinicopathological features were searched by computer from the inception to December 2021 in Pub Med,Web of Science,CNKI,Wanfang Data,and VIP.Meta-analysis was performed by Rev Man 5.4.Results A total of 13 literatures were included,including 1 080 ESCC patients.The results of meta-analysis showed that Beclin1 expression in ESCC group was lower than that in control group(OR=0.09,95%CI:0.05-0.17,P<0.000 01).Beclin1 expression in highly and moderately differentiated ESCC patients was higher than that in poorly differentiated ESCC patients(OR=2.01,95%CI:1.49-2.72,P<0.000 01).Beclin1 expression in ESCC patients with TNM stage Ⅰ-Ⅱ was higher than that in patients with stage Ⅲ-Ⅳ(OR=2.78,95%CI:1.76-4.41,P<0.000 1).Beclin1 expression in ESCC patients with infiltration depth from T_(1)-T_(2) was higher than that in T_(3)-T_(4) patients(OR=2.16,95%CI:1.58-2.97,P<0.000 01).Beclin1expression in ESCC patients without lymph node metastasis was higher than that in patients with lymph node metastasis(OR=0.26,95%CI:0.14-0.49,P<0.000 1).Conclusion Beclin1 expression is closely related to the clinicopathological features of ESCC,and Beclin1 may be an important target involved in the occurrence and development of ESCC.