Chiral Sulfide/Phosphoric Acid Cocatalyzed Enantioselective Intermolecular Oxysulfenylation of Alkenes with Phenol and Alcohol O-Nucleophiles

Enantioselective intermolecular three-component oxysulfenylations of alkenes with phenols and alcohols as O-nucleophiles were achieved using chiral BINAM-derived sulfide/phosphoric acid as the cocatalyst.Notably,chiral BINAM-derived sulfide/phosphoric acid co-catalysis was first explored to successfully catalyze highly enantioselective transformation.A variety of sulfur-containing benzylic aryl ethers and benzylic alkyl ethers,which contained two contiguous chiral stereocenters,were obtained readily in moderate to excellent yields with high to excellent enantioselectivities.