生酮饮食治疗儿童药物难治性癫痫的临床疗效研究

Clinical study of ketogenic diet in the treatment of drug-refractory epilepsy in children

目的评价生酮饮食(KD)治疗儿童药物难治性癫痫的疗效。方法84例药物难治性癫痫患儿为研究对象,随机将患儿分为对照组和观察组,每组42例。对照组采用常规抗癫痫治疗,观察组在对照组治疗基础上辅助KD治疗。比较两组治疗效果及各功能区发育商与生活质量。结果观察组治疗总有效率95.24%明显高于对照组71.43%,差异有统计学意义(P<0.05)。观察组适应性评分为(24.70±4.30)分、大运动评分为(33.80±4.50)分、精细动作评分为(32.50±3.50)分、语言评分为(29.90±3.50)分、个人-社交评分为(29.80±4.20)分、躯体功能评分为(56.80±3.50)分、情感健康评分为(66.60±3.50)分、行为能力评分为(57.70±3.20)分,均高于对照组的(20.80±3.40)、(29.50±3.50)、(26.10±3.30)、(25.50±3.30)、(25.50±3.30)、(53.03±2.30)、(64.30±2.20)、(54.30±2.30)分,差异有统计学意义(P<0.05)。结论在常规治疗基础上辅助KD治疗儿童药物难治性癫痫可以有效控制病情,提升患儿的发育商与生活质量。

Objective To evaluate the efficacy of ketogenic diet(KD)in the treatment of drug-refractory epilepsy in children.Methods A total of 84 children with drug-refractory epilepsy were studied,and the children were randomly divided into a control group and an observation group,with 42 cases in each group.The control group was treated with conventional antiepileptic therapy,and the observation group was treated with auxiliary KD on the basis of the control group.The therapeutic effect and the developmental quotient of each functional area and the quality of life were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.24%,which was significantly higher than 71.43%in the control group,and the difference was statistically significant(P<0.05).In the observation group,the adaptation score was(24.70±4.30)points,the gross motor score was(33.80±4.50)points,the fine motor score was(32.50±3.50)points,the language score was(29.90±3.50)points,the personal-social score was(29.80±4.20)points,the somatic function score was(56.80±3.50)points,the emotional health score was(66.60±3.50)points,and the behavioral ability score was(57.70±3.20)points,which were higher than(20.80±3.40),(29.50±3.50),(26.10±3.30),(25.50±3.30),(25.50±3.30),(53.03±2.30),(64.30±2.20),and(54.30±2.30)points in the control group,and the differences were statistically significant(P<0.05).Conclusion Auxiliary KD in the treatment of children with drug-refractory epilepsy can effectively control the condition and improve the developmental quotient and quality of life of the children.