盐酸替罗非班对急性心肌梗死冠脉介入治疗患者心功能及炎性因子的影响

Effect of tirofiban hydrochloride on cardiac function and inflammatory factors in patients undergoing percutaneous coronary intervention for acute myocardial infarction

目的探讨对急性心肌梗死患者在经皮冠状动脉(冠脉)介入治疗(PCI)基础上联用盐酸替罗非班治疗对改善患者心功能与炎性因子水平的作用。方法80例急性心肌梗死患者,随机分为实验组与对照组,各40例。对照组常规进行PCI治疗,实验组则在PCI术前进行血栓抽吸后予盐酸替罗非班治疗。比较两组临床疗效、炎性因子指标[白细胞介素(IL)-6、IL-10]、心功能指标[左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)]。结果实验组总有效率92.50%高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗后,两组IL-6、IL-10均优于治疗前,且实验组IL-6(3.17±0.96)ng/L低于对照组的(5.64±1.03)ng/L,IL-10(2.78±0.60)ng/L高于对照组的(2.14±0.51)ng/L,差异有统计学意义(P<0.05)。治疗后,两组LVEF、LVEDD、LVESD均优于本组治疗前,且实验组LVEF(0.70±0.07)高于对照组的(0.62±0.06),LVEDD(55.10±1.16)mm、LVESD(44.10±1.27)mm小于对照组的(58.74±1.24)、(46.28±1.35)mm,差异有统计学意义(P<0.05)。结论盐酸替罗非班治疗急性心肌梗死效果理想,能够提高患者心功能,可减轻机体炎性反应,值得推广。

Objective To discuss the effect of tirofiban hydrochloride on cardiac function and inflammatory factors in patients undergoing percutaneous coronary intervention(PCI)for acute myocardial infarction.Methods A total of 80 patients with acute myocardial infarction were randomly divided into an experimental group and a control group,with 40 patients in each group.The control group was routinely treated with PCI,while the experimental group was treated with tirofiban hydrochloride after thrombus aspiration prior to PCI.Both groups were compared in terms of clinical efficacy,inflammatory factor indexes[interleukin(IL)-6,IL-10],and cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),and left ventricular end-systolic diameter(LVESD)].Results The total effective rate 92.50%in the experimental group was higher than 75.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the IL-6 and IL-10 in both groups were better than those before treatment in this group;the IL-6(3.17±0.96)ng/L in the experimental group was lower than(5.64±1.03)ng/L in the control group,and IL-10(2.78±0.60)ng/L was higher than(2.14±0.51)ng/L in the control group;the differences were statistically significant(P<0.05).After treatment,the LVEF,LVEDD and LVESD in both groups were better than those before treatment;the LVEF(0.70±0.07)in the experimental group was higher than(0.62±0.06)in the control group;the LVEDD(55.10±1.16)mm and LVESD(44.10±1.27)mm in the experimental group were less than(58.74±1.24)and(46.28±1.35)mm in the control group;the differences were statistically significant(P<0.05).Conclusion Tirofiban hydrochloride has an ideal effect in the treatment of acute myocardial infarction,and can improve the heart function of patients,reduce the inflammatory reaction of the body,which is worth promoting.