平喘止咳汤治疗慢阻肺急性加重期的效果及对肺功能的影响分析

Analysis of the effect of Pingchuan Zhike Decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease and its influence on pulmonary function

目的探究平喘止咳汤治疗慢性阻塞性肺疾病(慢阻肺)急性加重期的疗效及对肺功能的影响。方法80例慢阻肺急性加重期患者,采用随机数字表法分为观察组和对照组,每组40例。对照组采用常规方案治疗,观察组采用平喘止咳汤治疗。比较两组临床疗效、症状(咳嗽咳痰、呼吸困难、喘息)缓解时间及治疗前后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、每分钟最大通气量(MVV)、第1秒用力呼气容积与用力肺活量的比值(FEV1/FVC)]。结果观察组治疗总有效率95.00%显著高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,两组FEV1、FVC、MVV、FEV1/FVC均高于治疗前,且观察组FEV1(3.25±0.40)L、FVC(3.72±0.50)L、MVV(90.21±10.17)L/min、FEV1/FVC(62.92±3.23)%均显著高于对照组的(2.85±0.21)L、(3.12±0.42)L、(80.18±8.28)L/min、(55.87±4.27)%,差异有统计学意义(P<0.05)。观察组咳嗽咳痰、呼吸困难及喘息缓解时间分别为(3.15±0.78)、(4.05±0.54)、(4.15±1.02)d,均明显短于对照组的(5.63±1.02)、(6.04±0.78)、(7.35±1.21)d,差异有统计学意义(P<0.05)。结论慢阻肺急性加重期应用平喘止咳汤治疗具有理想的效果,可显著改善患者肺功能,缩短症状缓解时间,值得应用。

Objective To investigate the efficacy of Pingchuan Zhike Decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease and its influence on pulmonary function.Methods A total of 80 patients with acute exacerbation of chronic obstructive pulmonary disease were divided into observation group and control group according to random numerical table,with 40 cases in each group.The control group was treated with conventional protocol,and the observation group was treated with Pingchuan Zhike Decoction.Both groups were compared in terms of clinical efficacy,the time to relief of symptoms(cough and sputum,dyspnea,wheezing)and the lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),maximum ventilation per minute(MVV),FEV1/FVC].Results The total effective rate of treatment in the observation group was 95.00%,which was significantly higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the FEV1,FVC,MVV,and FEV1/FVC in both groups were higher than those before treatment in this group;the observation group had FEV1 of(3.25±0.40)L,FVC of(3.72±0.50)L,MVV of(90.21±10.17)L/min,FEV1/FVC of(62.92±3.23)%,which were significantly higher than(2.85±0.21)L,(3.12±0.42)L,(80.18±8.28)L/min,(55.87±4.27)%in the control group,and the differences were statistically significant(P<0.05).The time to relief of cough and sputum,dyspnea and wheezing in the observation group were(3.15±0.78),(4.05±0.54)and(4.15±1.02)d,which were significantly shorter than(5.63±1.02),(6.04±0.78)and(7.35±1.21)d in the control group,and the differences were statistically significant(P<0.05).Conclusion Pingchuan Zhike Decoction has ideal effect in the treatment of acute exacerbation of chronic obstructive pulmonary disease,which can significantly improve the pulmonary function of patients and shorten the time of symptom relief,and is worthy of application.